New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Raúl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aránega Jiménez, José Carlos Prados Salazar y Consolación Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Raúl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, “they could be employed as an efficient tool in the treatment of these pathologies”.

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.
 
Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, “they could be employed as an efficient tool in the treatment of these pathologies”.

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

Ideal

Escrito por

Pág. 8 – Publicidad: Centro de Lenguas Modernas. Cursos de lenguas extranjeras

Pág. 9: Arte y reciclaje se dan la mano en unos premios

Pág. 10: Dos inteligencias nada artificiales

Pág. 15: Albolote reunirá este fin de semana un centenar de tunos de varias universidades

Pág. 22: Profesores brillantes en la Universidad

Descarga por URL: http://canal.ugr.es/medios-impresos/item/download/35665

Scientists develop new therapy for treatment of skin, lung cancer

Escrito por

Scientists at the University of Granada have developed a new therapy for the treatment of skin and lung cancer. This therapy involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.. Their studies have demostrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results obtained at the University of Granada revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Raúl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aránega Jiménez, José Carlos Prados Salazar y Consolación Melguizo Alonso.

In this study developed at the University of Granada, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

Experimental Approach

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action. To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72% and 35% respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80% of tumour regression within 8 days of treatment.

Raúl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The researcher points that they have already noticed the significant antitumour effects of gen E when employed separately. He also thinks that when this gene is combined with chemotherapy «it can reduce the effects of chemotherapy agents, which would allow the reduction of the dose required, as well as the reduction of side effects of chemotherapy».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New Therapy To Treat Lung and Skin Cancer Developed

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

Descargar

Granada Hoy

Escrito por

Pág. 14: La UGR busca fórmulas para evitar la ‘nueva’ precariedad laboral

Pág. 15: Granada producirá para el mercado mundial un ácido con acción anticancerígena

Pág. 16: Sólo uno de cada diez ciudadanos sabe lo que es el testamento vital

Pág. 18: Las imágenes más señeras de Granada

Pág. 40: Recortar la inversión en I+D puede comprometer el futuro

Pág. 58 – Publicidad: Aula Permanente de Formación Abierta. Programa Universitario para alumnos mayores

Pág. 59: La UGR ofrece hoy la lectura de Dinu Flamând, un símbolo literario de Rumanía

Descarga por URL: http://canal.ugr.es/medios-impresos/item/download/35663

Descargar

Un sistema inteligente permite diagnosticar el alzheimer de forma precoz

Escrito por

Investigadores del grupo de Procesado de Señal y Aplicaciones Biomédicas de la Universidad de Granada han diseñado un sistema inteligente que con precisión del 95 por ciento, podría anticipar el diagnóstico de la enfermedad de Alzheimer mediante un algoritmo de interpretación de imágenes cerebrales.

Este avance, que ha sido publicado recientemente en revistas como en «Physics in Medicine and Biology», es fruto de un proyecto de excelencia que la Consejería de Economía, Innovación y Ciencia ha incentivado con 159.668 euros, ha informado hoy InnovaPress.

La aplicación automatiza el diagnóstico y supera la actual interpretación de los resultados de un posible enfermo, que se realiza mediante la observación de las imágenes tomadas del cerebro, por lo que está sujeta a criterios subjetivos.

«Los facultativos admiten diferencia de criterio en el diagnóstico de enfermedades neurodegenerativas», según el responsable del proyecto, Javier Ramírez, que precisa que estas dificultades en el diagnóstico basado en imágenes médicas podría conducir a que no se detecte enfermedad en la fase inicial, «que precisamente ofrece la mejor oportunidad para tratar sus síntomas».

Para poner a punto el sistema, los investigadores procesan imágenes del cerebro adquiridas mediante técnicas de tomografía computerizada, tras la administración de un radiofármaco al paciente por vía intravenosa.

Así, circulan por su organismo sustancias emisoras de radiación que son detectadas por dispositivos que actúan a modo de escáner, de forma que los médicos obtienen información de cómo funcionan los órganos, según la investigación, que recoge datos sobre la actividad cerebral, como el flujo sanguíneo o la actividad metabólica.

«La utilización de nuevos radiofármacos como el 11C-PIB podría permitir además detectar el depósito de las placas de amiloide que suponen el primer paso de la patología», señala Ramírez.

Los investigadores cuentan con una base de datos con las imágenes del cerebro de un centenar de voluntarios donde se incluyen enfermos y personas sanas.

Con este material, han diseñado un algoritmo de clasificación automática que, al comparar una nueva imagen con las de muestra, es capaz de realizar su clasificación con una precisión cercana al 95 por ciento.

En el proyecto ha colaborado el Servicio de Medicina Nuclear del Hospital Virgen de las Nieves de Granada, que ha suministrado las imágenes cerebrales necesarias para preparar la base de datos con la que opera el sistema inteligente.

Aunque los expertos han centrado su proyecto en enfermedades neurodegenerativas, podría aplicarse a otro tipo de patologías, siempre que se cuente con una base de datos con la información de los pacientes.

Los expertos pretenden ahora evaluar el sistema desde el punto de vista clínico, aunque ya cuenta con el respaldo de la empresa andaluza Plataforma Tecnológica (PTEC) SA, que se ha comprometido a la explotación de los resultados mediante contrato previo de transferencia de resultados de investigación.

Descargar

La UGR organiza un recital de poesía china

Escrito por

La Universidad de Granada, a través del Seminario de Estudios Asiáticos del Secretariado de Extensión Universitaria y el Instituto Confucio de la Universidad de Granada, ha organizado un recital de poesía china tendrá lugar mañana en el Carmen de la Fundación Rodríguez-Acosta a las 21.00 horas.

Con el título “La poesía y la luna”, este recital se celebra en la conmemoración del Festival del Medio Otoño, una de las fiestas tradicionales más importantes de China según el calendario lunar. Durante esa noche se puede contemplar en el cielo la luna más redonda de todo el año, que para los chinos es un símbolo de unión familiar. En todas las culturas la luna ha sido una fuente de inspiración de sus poetas, pero quizás no haya habido pueblo que haya cantado y celebrado a la luna como lo ha hecho el pueblo chino.

Descargar