Scientists have developed a new therapy for the treatment of skin and lung cancer.
This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.
Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.
Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.
This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.
In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.