Portada: La UGR presenta su proyecto para optar al CEI a tres días de evaluación |El CDU de voleibol masculino encadena su cuarta victoria |Movilizaciones para salvar los Paseíllos Universitarios
Pág. 2: Francisco Álvarez |¿Cómo te afecta la crisis?
Pág. 4: Colaboración con el Consejo Audiovisual |I Jornada de Promoción de la Investigación |Elecciones a Claustro y Junta |Jornadas por los derechos sociales, económicos y culturales |Manifestación para salvar los Paseíllos Universitarios
Pág. 5: Convocatoria para solicitud de becas Erasmus |Luís Recalde repite en la Facultad de Farmacia |I Encuentro Hispano-Japonés sobre fronteras tecnológicas |La UGR presenta su proyecto para el CEI a tres días de su evaluación
Pág. 8: Salud es nombre de mujer |Atrapados en el hielo |I Muestra del Audiovisual Andaluz
Pág. 11: La vida “Erasmus” se vive intensamente
Pág. 14: III Torneo contra la Violencia de Género |Cuarta victoria del Voleibol Masculino en la liga FEV |CDU Waterpolo
Descargar
El País
ANDALUCÍA – Pág. 4: Arranca el consorcio del milenio del Reino de Granada |La búsqueda de fosas en Alfacar se ampliará
Pág. 32: El Gobierno falla los Campus de Excelencia
Descargar
Público
Pág. 26: Las universidades compiten por conseguir 150 millones de la UE
Pág. 38 – Agenda: Presentación/Granada
Descargar
El Mundo
Pág. 30: Señalan nuevas zonas para excavar en la fosa de Alfacar
Descargar
20 Minutos
Pág. 2: Música electroacústica
Pág. 4: Quieren su colegio profesional ya
Descargar
Granada Hoy
Portada: La UGR espera con espíritu de victoria la decisión del jurado sobre los campus de excelencia
Pág. 12 y 13: Espíritu de ganadores |Educación hará público hoy qué universidades conseguirán un CEI |Rumores, apuntes, aciertos y descartes |“La única vía para acceder a puestos cualificados” |“No basta con movilizar a los universitarios” |“Es el momento de plantearse lo que queremos ser”
Pág. 14: Los arqueólogos inician los trabajos en las fosas junto al monolito de Lorca
Pág. 21 – Publicidad: Convocatoria 2010/2011 de movilidad de estudiantes
Pág. 23: Última obra de López Aguilar |Noche de música electroacústica
Pág. 24: Los arabismos de los textos médicos medievales |Agenda: “Atrapados en el hielo”
Pág. 25: Agenda: “Caelum & Terra”
Pág. 61: Fernando Savater habla sobre “El laicismo, requisito de la democracia”
Pág. 64: La dimensión de Juan Habichuela, en la UGR
Descargar
Ideal
Pág. 7: Afloran más de 500 cadáveres de la necrópolis árabe del Triunfo
Pág. 12 – Publicidad: Convocatoria 2010/2011 de movilidad de estudiantes
Pág. 14: La excelencia de la UGR convence en Madrid |“Las impresiones son buenas”
Pág. 16: Fernando Savater reivindica la exclusión de las religiones de los ámbitos públicos
Pág. 20: Alcaldes aprenden a usar la “red” para comunicarse
Pág. 23 – Opinión: Hacia una Universidad de calidad y excelencia
Pág. 53: El curso sobre Morente organizado por la Universidad raspa el aprobado
Pág. 58: El mito de la Tierra plana
Pág. 59 – Agenda: Teatro clásico japonés |Música electroacústica |Charla sobre arabismos |“La aventura democrática” |La astronomía en los libros |“Stilitas” |“Atrapados en el hielo”
PARA LEER EL FUTURO – Pág. 17 – Publicidad: En la Universidad de Granada tú pones las metas
PARA LEER EL FUTURO – Pág. 50: “Leo con especial interés a los articulistas”
PARA LEER EL FUTURO – Pág. 51: “Encuentro información rápida de lo más importante”
PARA LEER EL FUTURO – Pág. 53: “Empiezo a leerlo por detrás”
Descargar
Gene increases effectiveness of drugs used to fight cancer and allows reduction in dosage
Gene increases effectiveness of drugs used to fight cancer and allows reduction in dosage
Researchers at the University of Granada have found a suicide gene, called \’gene E\’, which leads to the death of tumour cells derived from breast, lung and colon cancer, and prevents their growth. The importance of this new gene is that its use to fight cancer can reduce the potent drugs that are currently used, so that could mean more effective treatment for cancer.
This research was conducted by Ana Rosa Rama Ballesteros, from the Department of Anatomy and Human Embryology at the University of Granada, and directed by professors Antonia Aránega Jimenez, José Carlos Prados Salazar and Consolación Melguizo Alonso. Its aim was to study the possibility of reducing the dosage of drugs currently administered to cancer patients using combination therapy with suicide gene E.
Scientists from the UGR have shown that the bacteriophage phiX174 killer gene called E, can be used to induce death in tumour cells. So far, attempts to use many chemotherapeutic (cytotoxic) agents similar to the E gene have shown severe limitations resulting from their toxicity and their poor affinity with the tumour.
Advantages of gene therapy
As Ana Rosa Rama explains, chemotherapy, radiotherapy and surgery show at present «limited» results in advanced stages of cancer. «That is why it is urgent to find new therapies, and gene therapy has emerged as a potentially powerful therapeutic platform.» Her work has shown that «it is possible to use gene therapy as an aid to chemotherapy, improving its results when it comes to attacking cancer, thus allowing the dosage of agents to be reduced and contributing to a reduction in side effects for the patient.»
In order to understand how the E gene works, the researchers conducted studies using various techniques. The results indicate that the E gene\’s mechanism of action is to induce apoptosis (cell death), possibly through mitochondrial injury.
Therefore, they stress that «this new E gene appears as an ideal candidate to be transfected into tumour cells in order to induce apoptosis, possibly through mitochondrial activation, and to increase the sensitivity of these cells to the action of the drug developed specifically to act on them.»
The results of this research suggest the possibility of reducing the concentration of chemotherapeutic agents in current use with cancer patients. Thus, in lung cancer cell line A-549, scientists from the UGR achieved a 14% inhibition of tumour growth and reduced by 100 times the dose of Paclitaxel agent when it was combined with gene E. In the case of colon cancer, the results were similar. However, the most relevant fact was found in the breast cancer cell line MCF-7, in which the dose of the chemotherapeutic agent, doxorubicin, was reduced by 100 times, reaching up to a 21% greater inhibition of tumour proliferation when combined with gene E. Currently, researchers from the UGR are in the process of obtaining a patent for gene E.
Descargar
Gene Increases Effectiveness Of Drugs Used To Fight Cancer, Allows Dosage Reduction
Gene Increases Effectiveness Of Drugs Used To Fight Cancer, Allows Dosage Reduction
Researchers at the University of Granada have found a suicide gene, called \’gene E\’, which leads to the death of tumor cells derived from breast, lung and colon cancer, and prevents their growth. The importance of this new gene is that its use to fight cancer can reduce the potent drugs that are currently used, so that could mean more effective treatment for cancer.
This research was conducted by Ana Rosa Rama Ballesteros, from the Department of Anatomy and Human Embryology at the University of Granada, and directed by professors Antonia Aránega Jimenez, José Carlos Prados Salazar and Consolación Melguizo Alonso. Its aim was to study the possibility of reducing the dosage of drugs currently administered to cancer patients using combination therapy with suicide gene E.
Scientists from the UGR have shown that the bacteriophage phiX174 killer gene called E, can be used to induce death in tumor cells. So far, attempts to use many chemotherapeutic (cytotoxic) agents similar to the E gene have shown severe limitations resulting from their toxicity and their poor affinity with the tumor.
Advantages of gene therapy
As Ana Rosa Rama explains, chemotherapy, radiotherapy and surgery show at present «limited» results in advanced stages of cancer. «That is why it is urgent to find new therapies, and gene therapy has emerged as a potentially powerful therapeutic platform.» Her work has shown that «it is possible to use gene therapy as an aid to chemotherapy, improving its results when it comes to attacking cancer, thus allowing the dosage of agents to be reduced and contributing to a reduction in side effects for the patient.»
In order to understand how the E gene works, the researchers conducted studies using various techniques. The results indicate that the E gene\’s mechanism of action is to induce apoptosis (cell death), possibly through mitochondrial injury.
Therefore, they stress that «this new E gene appears as an ideal candidate to be transfected into tumor cells in order to induce apoptosis, possibly through mitochondrial activation, and to increase the sensitivity of these cells to the action of the drug developed specifically to act on them.»
The results of this research suggest the possibility of reducing the concentration of chemotherapeutic agents in current use with cancer patients. Thus, in lung cancer cell line A-549, scientists from the UGR achieved a 14% inhibition of tumor growth and reduced by 100 times the dose of Paclitaxel agent when it was combined with gene E. In the case of colon cancer, the results were similar. However, the most relevant fact was found in the breast cancer cell line MCF-7, in which the dose of the chemotherapeutic agent, doxorubicin, was reduced by 100 times, reaching up to a 21% greater inhibition of tumor proliferation when combined with gene E. Currently, researchers from the UGR are in the process of obtaining a patent for gene E.
Reference: Antonia Aránega Jiménez. Department of Anatomy and Human Embryology, University of Granada.
Image Caption: This image shows the effect of gene therapy combined with cytotoxic agents in E spheroids derived from breast cancer cell line MCF-7. A. Control; B. Doxorubicin 10nm, C. Paclitaxel 10nm, D. Docetaxel 10nm, combined with gene E. Credit: University of Granada
Descargar
Increases Effectiveness Of Drugs Used To Fight Cancer And Allows Reduction In Dosage
Increases Effectiveness Of Drugs Used To Fight Cancer And Allows Reduction In Dosage
Researchers at the University of Granada have found a suicide gene, called \’gene E\’, which leads to the death of tumour cells derived from breast, lung and colon cancer, and prevents their growth. The importance of this new gene is that its use to fight cancer can reduce the potent drugs that are currently used, so that could mean more effective treatment for cancer.
This research was conducted by Ana Rosa Rama Ballesteros, from the Department of Anatomy and Human Embryology at the University of Granada, and directed by professors Antonia Aránega Jimenez, José Carlos Prados Salazar and Consolación Melguizo Alonso. Its aim was to study the possibility of reducing the dosage of drugs currently administered to cancer patients using combination therapy with suicide gene E.
Scientists from the UGR have shown that the bacteriophage phiX174 killer gene called E, can be used to induce death in tumour cells. So far, attempts to use many chemotherapeutic (cytotoxic) agents similar to the E gene have shown severe limitations resulting from their toxicity and their poor affinity with the tumour.
Advantages of gene therapy
As Ana Rosa Rama explains, chemotherapy, radiotherapy and surgery show at present «limited» results in advanced stages of cancer. «That is why it is urgent to find new therapies, and gene therapy has emerged as a potentially powerful therapeutic platform.» Her work has shown that «it is possible to use gene therapy as an aid to chemotherapy, improving its results when it comes to attacking cancer, thus allowing the dosage of agents to be reduced and contributing to a reduction in side effects for the patient.»
In order to understand how the E gene works, the researchers conducted studies using various techniques. The results indicate that the E gene\’s mechanism of action is to induce apoptosis (cell death), possibly through mitochondrial injury.
Therefore, they stress that «this new E gene appears as an ideal candidate to be transfected into tumour cells in order to induce apoptosis, possibly through mitochondrial activation, and to increase the sensitivity of these cells to the action of the drug developed specifically to act on them.»
The results of this research suggest the possibility of reducing the concentration of chemotherapeutic agents in current use with cancer patients. Thus, in lung cancer cell line A-549, scientists from the UGR achieved a 14% inhibition of tumour growth and reduced by 100 times the dose of Paclitaxel agent when it was combined with gene E. In the case of colon cancer, the results were similar. However, the most relevant fact was found in the breast cancer cell line MCF-7, in which the dose of the chemotherapeutic agent, doxorubicin, was reduced by 100 times, reaching up to a 21% greater inhibition of tumour proliferation when combined with gene E. Currently, researchers from the UGR are in the process of obtaining a patent for gene E.
Descargar
Una experiencia piloto permite mejorar el rendimiento escolar de niñas y niños gitanos
Una experiencia piloto permite mejorar el rendimiento escolar de niñas y niños gitanos
Investigadores de la Universidad de Granada y de la Universidad Nacional del Comahue (Argentina) han diseñado un programa de intervención educativa que ha permitido integrar al 100% a la población gitana en las aulas de un Centro de Educación Secundaria de la provincia de Granada.
Este plan, que se ha desarrollado durante dos cursos académicos, ha servido para mejorar el rendimiento escolar de los niños de etnia gitana y normalizar completamente la relación con sus compañeros.
Este trabajo ha sido elaborado por Sonia Cristina Iguacel y dirigido por Leonor Buendía Eisman, del departamento de Métodos de Investigación y Diagnóstico en Educación de la Universidad de Granada.
Para llevarlo a cabo, su autora trabajó directamente con el profesorado y con alumnos de origen gitano, de 1º ESO, con calificaciones muy bajas, absentismo escolar, numerosos partes disciplinarios y episodios conflictivos, y con un nivel de competencia curricular propio de un 2º y 3º de primaria, destinatarios del Plan de Compensación Educativa del centro escolar.
Iguacel utilizó diferentes estrategias de recogida de información durante todo el proceso de su investigación: un diario de campo, entrevistas en profundidad, registros fotográficos y en vídeo, un estudio de documentación producida en el centro, etc.
Aulas más inclusivas
El objetivo general de la investigación ha sido la construcción de aulas más inclusivas en un Centro de Educación Secundaria de la provincia de Granada. Para lograrlo, siguieron un proceso de investigación-acción durante dos cursos académicos. Comenzaron con un diagnóstico y evaluación de la situación del plan de compensatoria en el Centro y posteriormente procedieron a la elaboración, ejecución y evaluación de un programa de intervención en dichas aulas. Las investigadoras encontraron que todo el alumnado asignado a la clase de compensatoria pertenecía al pueblo gitano, por lo que todo el trabajo del primer año se realizó con estos alumnos.
Este trabajo se posiciona dentro del modelo de “educación inclusiva”, por lo que su pretensión básica es el logro de un centro educativo que no excluya a una parte de su alumnado por su pertenencia cultural y étnica, ni promueva como respuesta a esas peculiaridades la creación de aulas específicas y el diseño de prácticas docentes segregadoras que perpetúen así situaciones de desigualdad escolar y social y que dificulten la inclusión de este alumnado en la sociedad en condiciones de equidad con respecto al resto de la población no gitana.
Posicionamiento activo
Gracias a esta experiencia piloto, el alumnado de Compensatoria de 1º de ESO que participó obtuvo un posicionamiento muy activo y participativo en la dinámica del aula y del centro; disminuyó casi por completo el desfase curricular en el Ámbito Socio-lingüístico; disminuyeron mucho los episodios conflictivos y sanciones disciplinarias, se logró una mayor regulación de la asistencia a clases, y varias familias se implicaron en el proceso de aprendizaje de sus hijos y en las actividades del centro.
La labor del equipo directivo y de la profesora de compensatoria fue decisiva para integrar a este alumnado en clases regulares.
La experta cree que es absolutamente necesario “generar otra escuela pública, más respetuosa y atenta a la diversidad de su alumnado, no sólo desde declaraciones políticamente correctas sino también desde cada una de las prácticas que allí se realizan”.
Uno de los aspectos más originales de este trabajo es que ha demostrado que una práctica docente integradora no se agota con la “inclusión” de los alumnos y alumnas de diferentes procedencias y condiciones en una misma clase, “sino de que se debe apostar por la construcción conjunta del conocimiento, por el aprendizaje de competencias que les permitan una vida escolar y social activa, y eso sólo se puede lograr si, desde pequeños, los niños y las niñas se educan en un ambiente plural y democrático”.
Los resultados de esta investigación darán lugar a varios artículos científicos, e incluso una monografía que será publicada próximamente.
Descargar
Gene increases effectiveness of drugs used to fight cancer and allows reduction in dosage
Gene increases effectiveness of drugs used to fight cancer and allows reduction in dosage
Researchers at the University of Granada have found a suicide gene, called \’gene E\’, which leads to the death of tumour cells derived from breast, lung and colon cancer, and prevents their growth. The importance of this new gene is that its use to fight cancer can reduce the potent drugs that are currently used, so that could mean more effective treatment for cancer. This research was conducted by Ana Rosa Rama Ballesteros, from the Department of Anatomy and Human Embryology at the University of Granada, and directed by professors Antonia Aránega Jimenez, José Carlos Prados Salazar and Consolación Melguizo Alonso. Its aim was to study the possibility of reducing the dosage of drugs currently administered to cancer patients using combination therapy with suicide gene E.
Scientists from the UGR have shown that the bacteriophage phiX174 killer gene called E, can be used to induce death in tumour cells. So far, attempts to use many chemotherapeutic (cytotoxic) agents similar to the E gene have shown severe limitations resulting from their toxicity and their poor affinity with the tumour.
Advantages of gene therapy
As Ana Rosa Rama explains, chemotherapy, radiotherapy and surgery show at present «limited» results in advanced stages of cancer. «That is why it is urgent to find new therapies, and gene therapy has emerged as a potentially powerful therapeutic platform.» Her work has shown that «it is possible to use gene therapy as an aid to chemotherapy, improving its results when it comes to attacking cancer, thus allowing the dosage of agents to be reduced and contributing to a reduction in side effects for the patient.»
In order to understand how the E gene works, the researchers conducted studies using various techniques. The results indicate that the E gene\’s mechanism of action is to induce apoptosis (cell death), possibly through mitochondrial injury.
Therefore, they stress that «this new E gene appears as an ideal candidate to be transfected into tumour cells in order to induce apoptosis, possibly through mitochondrial activation, and to increase the sensitivity of these cells to the action of the drug developed specifically to act on them.»
The results of this research suggest the possibility of reducing the concentration of chemotherapeutic agents in current use with cancer patients. Thus, in lung cancer cell line A-549, scientists from the UGR achieved a 14% inhibition of tumour growth and reduced by 100 times the dose of Paclitaxel agent when it was combined with gene E. In the case of colon cancer, the results were similar. However, the most relevant fact was found in the breast cancer cell line MCF-7, in which the dose of the chemotherapeutic agent, doxorubicin, was reduced by 100 times, reaching up to a 21% greater inhibition of tumour proliferation when combined with gene E. Currently, researchers from the UGR are in the process of obtaining a patent for gene E.
Descargar