New therapy for lung and skin cancer found

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Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Raúl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aránega Jiménez, José Carlos Prados Salazar y Consolación Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Raúl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, “they could be employed as an efficient tool in the treatment of these pathologies”.

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

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New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

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New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.
 
Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

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New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, “they could be employed as an efficient tool in the treatment of these pathologies”.

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

Descargar

New therapy for lung and skin cancer found

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action.

To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72pc and 35pc respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80pc of tumour regression within 8 days of treatment.

Razl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

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Ideal

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Pág. 8 – Publicidad: Centro de Lenguas Modernas. Cursos de lenguas extranjeras

Pág. 9: Arte y reciclaje se dan la mano en unos premios

Pág. 10: Dos inteligencias nada artificiales

Pág. 15: Albolote reunirá este fin de semana un centenar de tunos de varias universidades

Pág. 22: Profesores brillantes en la Universidad

Descarga por URL: http://canal.ugr.es/medios-impresos/item/download/35665

Scientists develop new therapy for treatment of skin, lung cancer

Escrito por

Scientists at the University of Granada have developed a new therapy for the treatment of skin and lung cancer. This therapy involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.. Their studies have demostrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results obtained at the University of Granada revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Raúl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aránega Jiménez, José Carlos Prados Salazar y Consolación Melguizo Alonso.

In this study developed at the University of Granada, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

Experimental Approach

This is an experimental technique that could be used in clinical tests in the future. This new therapy was also tested on the lung adenocarcinoma A549 line. Then, they studied how these genes affect cell proliferation -both in vitro and in vivo experiments- and their mechanism of action. To such purpose, they studied the alterations that such genes render on outer mitochondrial membranes, and carried out cell-death tests and cell and tissue morphology analysis through microscopy techniques.

Tumour growth inhibition in cultured cells of gene E and gef within 72 hours was 72% and 35% respectively, in comparison to in vivo experiments. Gen E action on melanoma tumours induced in mice was 70-80% of tumour regression within 8 days of treatment.

Raúl Ortiz Quesada stated that in a near future, when genetic therapies allow to improve the controlled expression of these genes in tumour cells, and reduce the risks involved in their clinical use, «they could be employed as an efficient tool in the treatment of these pathologies».

The researcher points that they have already noticed the significant antitumour effects of gen E when employed separately. He also thinks that when this gene is combined with chemotherapy «it can reduce the effects of chemotherapy agents, which would allow the reduction of the dose required, as well as the reduction of side effects of chemotherapy».

The results of this research were published in prestigious scientific journal within the field of Oncology (as Journal of Molecular Medicine) or Dermatology (as in Experimental Dermatology).

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New Therapy To Treat Lung and Skin Cancer Developed

Escrito por

Scientists have developed a new therapy for the treatment of skin and lung cancer.

This therapy, developed by at the University of Granada researchers, involves the use of a suicide coliphage-gene (gene E) that can induce death to cells transfected with it.

Their studies have demonstrated that this technique is not only effective in vitro (using tumour cell cultures), but also in vivo through the use of experimental animals in which tumours were induced.

Although further research is required, the results revealed gene E’s intensive antitumour activity, which means that it could be used in new treatments for this type of pathology.

This study was carried out by Razl Ortiz Quesada, from the Department of Human Anatomy and Embriology, at the University of Granada, and led by professors Antonia Aranega Jiminez, Josi Carlos Prados Salazar y Consolacisn Melguizo Alonso.

In this study, gene E and gene gef -which are bacterial lysis genes- were employed. This is the first time that this type of genes is used in eukaryotic cells in the treatment of tumours. During the in vitro tests, the researchers studied the effect of these genes on the B16-F10 melanoma line. This line was then used to generate tumours in vivo and analyse their effect.

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Granada Hoy

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Pág. 14: La UGR busca fórmulas para evitar la ‘nueva’ precariedad laboral

Pág. 15: Granada producirá para el mercado mundial un ácido con acción anticancerígena

Pág. 16: Sólo uno de cada diez ciudadanos sabe lo que es el testamento vital

Pág. 18: Las imágenes más señeras de Granada

Pág. 40: Recortar la inversión en I+D puede comprometer el futuro

Pág. 58 – Publicidad: Aula Permanente de Formación Abierta. Programa Universitario para alumnos mayores

Pág. 59: La UGR ofrece hoy la lectura de Dinu Flamând, un símbolo literario de Rumanía

Descarga por URL: http://canal.ugr.es/medios-impresos/item/download/35663

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El rector destaca “La elevada repercusión económica y social de nuestra Universidad en Granada y en su provincia”

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El rector de la Universidad de Granada, Francisco González Lodeiro, ha inaugurado el miércoles 22 de septiembre, las Jornadas de auditoría y control en las Universidades 2010, que se celebran en el salón de actos del Complejo Triunfo, y en las que participan representantes de más de 30 universidades y de órganos de control externo de las comunidades autónomas, además de empresas de auditoría y el Ayuntamiento de Granada.

El rector definió el Control Interno en una universidad “como el Control de los Controles, como el conjunto de mecanismos cuyos fines son innatos en la universidad, como garantizar el uso eficiente de los recursos, velar por el cumplimiento de la legalidad vigente, salvaguardar y proteger el patrimonio y, en definitiva, preservar que la gestión dentro de la institución se realiza de manera congruente con los cometidos que la sociedad nos tiene encomendados”.

En su intervención ante los participantes en las jornadas el rector destacó “la elevada repercusión económica y social de nuestra Universidad en Granada y en su provincia”. Subrayó que “Contamos con una plantilla de trabajadores que ronda los 6.000 efectivos, a lo que hay que añadir una cifra igual de empleos indirectos, contratados por proveedores y suministradores. Estas cifras, unidas a los más de 82.000 estudiantes –o clientes desde un enfoque de gestión más moderno- a los que prestamos servicios, hacen que la gestión de cualquier departamento o servicio de la Universidad de Granada, como es el caso de la Oficina de Control Interno, adquiera consecuencias muy notables, tanto internas como externas, en la medida en que sus resultados afectan a muy numerosos y variados colectivos, que van desde empleados universitarios hasta suministradores de bienes y servicios y la sociedad en general”.

 

Pie de foto: Asistentes a la inauguración: (De izda a drcha):

-Juan Antonio Mérida Velasco. Segundo Teniente Alcalde. Delegado del Área de Economía, Hacienda y Comunicación del Ayuntamiento de Granada.

-Antonio López Hernández. Comisionado Fundación General de la Universidad.

-Francisco González Lodeiro. Rector de la Universidad de Granada.

-Virtudes Molina Espinar. Secretaria del Consejo Social de la Universidad de Granada.

-Andrés Navarro Galera. Director de la Oficina Económica.

El presidente de la Fundación Movilidad Sostenible y Segura de Cataluña, Pau Noy, participa en un seminario organizado por la UGR

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Tendrá lugar en la Sala de Juntas de la E.T.S. de Ingeniería de Caminos, Canales y Puertos, el viernes, 24 de septiembre de 2010, a las 18 horas

El presidente de la Fundación Movilidad Sostenible y Segura de Cataluña, Pau Noy, participa en un seminario organizado por la UGR, el viernes, 24 de septiembre de 2010, a las 18 horas.

El acto, que tendrá lugar en la Sala de Juntas de la E.T.S. de Ingeniería de Caminos, Canales y Puertos, ha sido organizado por el Seminario de Medio Ambiente y Calidad de Vida/Cátedra “José Saramago” de la UGR.

Esta actividad se celebra aprovechando la actual coyuntura en la que se encuentra la ciudad de Granada en lo que concierne a la movilidad, tras la reciente aprobación de la Ordenanza Municipal de Circulación de Peatones y Ciclistas, la inminente puesta en marcha del servicio de préstamo de bicicletas por parte del Ayuntamiento, la cada vez más avanzada línea 1 del metro ligero y las polémicas suscitadas por los proyectos de la Ronda Este, la Segunda Circunvalación y el Distribuidor Sur de la autovía para descongestionar el tráfico en vehículo privado, y aprovechando la visita a la ciudad de Pau Noy (Presidente de la Fundación Movilidad Sostenible y Segura de Cataluña, asesor técnico de la PTP y promotor junto a algunas asociaciones ecologistas de la “Grenelle” de la Movilidad en España), se plantea organizar un seminario, reuniendo a los principales colectivos sociales, académicos y empresariales involucrados en estos temas en la ciudad, para compartir experiencias y recuperar el debate.

Los grupos participantes son: Biciescuela Granada; Granada al Pedal; No a la Ronda Este; Ecomovilidad; No al Distribuidor Sur; Salvemos la Vega; y José Luis Cañabate.

Contacto: Profesor Alberto Matarán Ruiz. Director del Seminario de Medio Ambiente y Calidad de Vida-Cátedra “José Saramago”. Secretariado de Extensión Universitaria, Universidad de Granada. Tfn: 958 240447. Correo electrónico: mataran@ugr.es