IDENTIFICAN POR PRIMERA VEZ COMBINACIONES DE GENES RELACIONADAS CON LA OSTEOPOROSIS DE CADERA EN MUJERES POSTMENOPÁUSICAS

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Científicos de la UGR determinan que las mujeres que sufren esta enfermedad presentan, como media, dos años menos de vida fértil que las pacientes sanas.

Las mujeres que sufren osteoporosis de cadera presentan, como media, dos años menos de vida fértil que las pacientes sanas, según un estudio realizado en la Universidad de Granada. Además, aunque es necesario profundizar en esta línea de investigación, los científicos han encontrado, al menos, tres marcadores genéticos relacionados con la osteoporosis de cadera en mujeres postmenopáusicas.

La osteoporosis de cadera es una enfermedad que predispone a la fractura, lo que resulta muy invalidante para la persona que la padece además de tener un enorme impacto sanitario. El trabajo de la UGR pretendía conocer los factores que predisponen al desarrollo de la enfermedad, siendo conscientes de la importancia que tiene la genética, ya que hasta el 80% de la formación del hueso está determinada genéticamente.

Para llevar a cabo este trabajo, sus autores realizaron un estudio multicéntrico, entre cinco clínicas españolas, recogiendo a las pacientes entre mujeres postmenopáusicas que acudían a las consultas de ginecología. En total, reclutaron cerca de 2.000 mujeres, a las cuales se les realizó una detallada historia clínica, investigando diferentes factores de riesgo conocidos para la osteoporosis de cadera y otros no tan investigados, como por ejemplo la dieta mediterránea. A las mujeres se les realizó una extracción sanguínea, para la determinación de los marcadores genéticos, y una densitometría para estudiar la densidad mineral ósea en la columna y cadera.

Una enfermedad compleja y multifactorial

Esta investigación ha sido realizada por Jesús Carlos Presa Lorite del departamento de Obstetricia y Ginecología de la Universidad de Granada, y dirigida por los profesores Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Los científicos pretendían avanzar en el conocimiento de una enfermedad compleja y multifactorial, la osteoporosis, investigando cómo la genética influye en el desarrollo de esta enfermedad y ahondando en el conocimiento de cuáles pueden ser los genes más determinantes.

Los resultados de este trabajo apuntan que ciertas combinaciones de genes pueden favorecer la osteoporosis de cadera, si bien “hay que interpretarlos con mucha cautela, según apuntan los investigadores. “Puede que en un futuro, quizás no muy lejano, se pueda hacer un estudio genético a las pacientes en las consultas para indicarles la posibilidad de padecer una fractura de cadera y si tiene que realizar determinados tratamientos”, destaca Presa Lorite.

Parte de los resultados de este trabajo han sido reconocidos por la Real Academia de Medicina del Distrito de Granada (Andalucía Oriental) con el Premio “Clínica Abril”, correspondiente a la convocatoria del año 2009.

Referencia bibliográfica:

Risk factors associated with osteoporosis in Spanish postmenopausal women: the benefit of Mediterranean and Atlantic diets. Santalla A, Mendoza N, Vázquez F, Martínez-Astorquiza T, Quereda F, Sánchez Borrego R, Morón F, González A, Presa J. Climateric. May 2008. Volume 11 Supplement 2; 258.

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La UGR convoca los premios a la excelencia en la movilidad internacional de estudiantes

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La Universidad de Granada ha establecido tres premios por valor de 1.000 euros cada uno, correspondiendo uno a la rama de Artes y Humanidades, uno a la rama de Ciencias Sociales y Jurídicas y uno a las ramas de Ciencias Experimentales, Ciencias de la Salud, Arquitecturas e Ingenierías. Estos tres premios se otorgarán a los estudiantes de estas ramas que demuestren haber sacado el máximo aprovechamiento de su estancia internacional.  

Para poder optar a estos premios los estudiantes de la UGR deben haber realizado una movilidad internacional en el marco de las Convocatorias PAP-Erasmus, Programa Propio de la UGR u otros programas gestionados a través del Vicerrectorado de Relaciones Internacionales durante el curso 2009/2010, haber superado todos los créditos incluidos en sus acuerdos de estudios correspondientes y acreditar al menos el nivel B2 de una lengua extranjera.

La comisión evaluadora valorará toda actividad que demuestre el valor añadido de la movilidad para cada solicitante, siempre y cuando esté debidamente acreditada y justificada, así como la calidad de la memoria presentada y los logros obtenidos, la motivación, la capacidad de comunicación de los participantes y el interés de la experiencia.

Los estudiantes que deseen optar a estos premios deben presentar sus solicitudes en la Oficina de Relaciones Internacionales hasta las 14 horas del día 26 de abril de 2011. La convocatoria, requisitos y formulario de solicitud para optar a estos premios que concede la Universidad de Granada (UGR) pueden consultarse en la página web del Vicerrectorado de Relaciones Internacionales de la UGR.

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Gene combinations are found to be related to hip osteoporosis in postmenopausal women

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Women with osteoporosis in their hip suffer menopause two years earlier than healthy women,  a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.

For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis –as the Mediterranean diet– were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease

This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition,  studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, “these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment” –Presa Lorite states.

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Gene combinations are found to be related to hip osteoporosis in postmenopausal women

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Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.

For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis -as the Mediterranean diet- were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease
This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition, studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, «these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment» -Presa Lorite states.

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Gene Combinations Are Found To Be Related To Hip Osteoporosis In Postmenopausal Women

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Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.

For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis as the Mediterranean diet were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease

This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Angel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition, studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, «these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment» Presa Lorite states.

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Gene combinations are found to be related to hip osteoporosis in postmenopausal women

Escrito por

Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.

For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis –as the Mediterranean diet– were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition, studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, «these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment» –Presa Lorite states.

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Gene Combinations Are Found To Be Related To Hip Osteoporosis In Postmenopausal Women

Escrito por

Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.
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For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis –as the Mediterranean diet– were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition, studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, «these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment» –Presa Lorite states.

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Gene combinations are found to be related to hip osteoporosis in postmenopausal women

Escrito por

Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women. Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.

For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis –as the Mediterranean diet– were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition, studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, «these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment» –Presa Lorite states.

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Melilla Hoy

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Pág. 13: Imbroda no descarta unas enseñanzas universitarias en el ámbito privado si no obtubiera mayor desarrollo con la Universidad de Granada

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Gene combinations are found to be related to hip osteoporosis in postmenopausal women

Escrito por

Women with osteoporosis in their hip suffer menopause two years earlier than healthy women, a study conducted at the University of Granada says. Additionally, although further study is required, researchers have found at least three genetic markers associated with osteoporosis in the hip in postmenopausal women.

Osteoporosis in the hip increases the risk of suffering fractures, which is extremely disabling for the patient, and represents a high cost for the health public system. The aim of this research study developed at the University of Granada was to understand the factors that increase the risk of developing osteoporosis. As a starting point, researchers took the relevance of genes in this disease, since 80% of bone formation is genetically determined.

For the purpose of this study, authors conducted a multi-center study involving five Spanish clinics. A sample of 2,000 patients was taken from the gynecology services of the partipating clinics. Detailed medical records were prepared of each patient including those risk factors known to intervene in osteoporosis of the hip. In addition, other factors that have not still been proved to intervene in osteoporosis –as the Mediterranean diet– were also studied. Blood collections were made to analyse genetic markers, and a densitrometry was done to study bone mineral density in spine and hip.

A Complex and Multifactor Disease This study was developed by Jesús Carlos Presa Lorite at the Department of Obstetrics of the University of Granada and conducted by professors Nicolás Mendoza Ladrón de Guevara, Ángel Alejandro Santalla Hernández y Alberto Salamanca Ballesteros. Scientists intended to further understand the process of this complex and multifactor condition, studying how genetics affect the development of this condition and further analysing which genes are the most determinant.

The results obtained proved that certain gene combinations may increase the risk of suffering osteoporosis. However, “these results should be considered cautiously. Maybe that, in the short-term, a genetic study of patients could be made, to inform them when they are found to be prone to suffer a hip fracture, and to recommend them to follow some specific treatment” –Presa Lorite states.

References: Risk factors associated with osteoporosis in Spanish postmenopausal women: the benefit of Mediterranean and Atlantic diets. Santalla A, Mendoza N, Vázquez F, Martínez-Astorquiza T, Quereda F, Sánchez Borrego R, Morón F, González A, Presa J. Climateric. May 2008. Volume 11 Supplement 2; 258.

Contact: Jesús Carlos Presa Lorite. Department of Obstetrics and Gynecology, University of Granada. Cell phone: +34 655 764 234. E-mail Address: jpresalorite@hotmail.com

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20 Minutos

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Pág. 5 – Publicidad: Premios a la excelencia en la movilidad internacional de estudiantes

Publicidad: XI Feria Internacional de Empleo Universitario 6 y 7 de Abril de 2011

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El Mundo

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G / U / CAMPUS – Pág. 7: Psicología. Alumnos de bachillerato, discriminados en Selectividad

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