Odontólogos de la Universidad de Granada reciben un reconocimiento por su labor en la investigación científica

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l equipo de investigadores liderado por el Prof. Dr. Gerardo Gómez Moreno de la Facultad de Odontología de la Universidad de Granada ha recibido el Premio Pablo Gálvez Pruñonosa por la investigación: «Evaluación de la eficacia de un sialogogo tópico en spray con ácido málico 1% en personas mayores con xerostomía: Un ensayo Clínico aleatorizado a doble ciego».

Este galardón es un reconocimiento de la Real Academia de Medicina y Cirugía de Andalucía Oriental dirigido a odontólogos, estomatólogos y licenciados en Medicina.

La entrega del Premio tuvo lugar en el Salón de Actos de la Real Academia de Medicina de Andalucía Oriental, durante la Solemne sesión inaugural del curso 2013. Una centenaria institución con sede en Granada a la que pertenecen profesores de Universidad y distintos profesionales de la Medicina y otras ciencias sanitarias no solo de Granada sino de las provincias de su entorno más inmediato: Almería, Jaén, Málaga y Melilla. Es un prestigioso organismo médico-consultivo, miembro del Instituto de Academias de Andalucía.

¿Qué es la xerostomía?

La xerostomía es un trastorno también conocido como ‘boca seca’. En la actualidad afecta al 40% de la población adulta mayor de 55 años y en personas de 60 puede llegar al 90%, en pacientes hospitalizados. La falta de humectación en la boca puede provocar manifestaciones clínicas que hacen que disminuya la calidad de vida del paciente. Las dificultades más frecuentes se presentan en la masticación, la fonación y alteraciones gustativas. Además, la disminución de la saliva afecta a los tejidos blandos (mucosa) y dientes.

Sobre los tejidos blandos, la xerostomía produce desecación, traumatismos, inflamaciones, úlceras doloras e infecciones locales. Los efectos sobre los dientes pueden ser la caries y la sensibilidad dental.

Las causas ambientales que favorecen su aparición pueden ser la ansiedad, el consumo de tabaco y la radioterapia.

Compromiso con la Comunidad científica

Establecer estrechos lazos de colaboración con prestigiosas universidades españolas, europeas y americanas es uno de los compromisos de DENTAID. Esta interesante relación ha permitido obtener datos relevantes que enriquecen la investigación diaria de la compañía, avalando la calidad de todos sus productos.

Gracias a un exigente equipo de investigadores, la compañía especializada en Salud bucodental puede ir innovando y ofreciendo continuamente conocimiento de alto valor para la comunidad científica. Una I+D+i de calidad es la gran apuesta de DENTAID, que se traduce en un aumento constante de los recursos y personal dedicado a esta materia. La ciencia es uno de los valores más preciados para DENTAID.

Acerca de DENTAID

DENTAID es una compañía internacional con sede en Barcelona especializada en salud bucal.

Es pionera en investigación y desarrollo de productos bucales de última generación para la prevención, diagnóstico y tratamiento de enfermedades producidas por el biofilm oral (placa bacteriana). DENTAID cuenta con uno de los laboratorios de I+D+i en microbiología oral más importante de Europa.

La compañía ha crecido hasta convertirse en líder en higiene bucal en farmacia con presencia internacional a través de una amplia red de distribuidores.

Entre los productos que comercializa se encuentran marcas como: VITIS®, Perio·Aid®, Desensin®, Interprox®, Halita®, Xeros® DENTAID, Waterpik® y Fittydent®. Además, DENTAID es miembro de las principales sociedades odontológicas españolas e internacionales.

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Direct link between exposure to pesticides in food, air and water and prevalence of type 2 diabetes

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A study led by the University of Granada reveals that there is a direct relationship between the presence of Persistent Organic Pollutants in the body and the development of type 2 diabetes, regardless of the patient’s age, gender or body mass index.

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index. These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body.

In a paper recently published in the journal Environmental Research, researchers demonstrate that people with higher concentrations of DDE -the main metabolite in the pesticide DDT- are four times more likely to develop type 2 diabetes than other people. In addition, the risk of type 2 diabetes is also associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.

A Study with 386 Subjects

To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)».

This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin.

According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.»

The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4% of the world population have this metabolic disorder. This will have a severe impact on public health programs, since it is highly resource-consuming. The factors causing such increase in the prevalence of diabetes are not still clearly understood.

This research study was conducted by researchers at San Cecilio University Hospital, Granada, the University of Granada and the Andalusian School of Public Health, Santa Ana hospital, Motril, and the Hospital del Mar d’Investigacions Mèdiques, Barcelona. According to the authors of the study «we are an example of clinical research focused on common diseases with a high impact on health».

Descargar

Direct link between exposure to pesticides in food, air and water and prevalence of type 2 diabetes

Escrito por

A study led by the University of Granada reveals that there is a direct relationship between the presence of Persistent Organic Pollutants in the body and the development of type 2 diabetes, regardless of the patient’s age, gender or body mass index.

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index. These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body.

In a paper recently published in the journal Environmental Research, researchers demonstrate that people with higher concentrations of DDE -the main metabolite in the pesticide DDT- are four times more likely to develop type 2 diabetes than other people. In addition, the risk of type 2 diabetes is also associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.

A Study with 386 Subjects

To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)».

This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin.

According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.»

The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4% of the world population have this metabolic disorder. This will have a severe impact on public health programs, since it is highly resource-consuming. The factors causing such increase in the prevalence of diabetes are not still clearly understood.

This research study was conducted by researchers at San Cecilio University Hospital, Granada, the University of Granada and the Andalusian School of Public Health, Santa Ana hospital, Motril, and the Hospital del Mar d’Investigacions Mèdiques, Barcelona. According to the authors of the study «we are an example of clinical research focused on common diseases with a high impact on health».

Descargar

Researchers find exposure to pesticides in food, air and water increases risk of type 2 diabetes

Escrito por

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index. These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body. In a paper recently published in the journal Environmental Research, researchers demonstrate that people with higher concentrations of DDE –the main metabolite in the pesticide DDT– are four times more likely to develop type 2 diabetes than other people. In addition, the risk of type 2 diabetes is also associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano. A study with 386 subjects To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)». This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin. According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.» The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4% of the world population have this metabolic disorder. This will have a severe impact on public health programs, since it is highly resource-consuming. The factors causing such increase in the prevalence of diabetes are not still clearly understood. This research study was conducted by researchers at San Cecilio University Hospital, Granada, the University of Granada and the Andalusian School of Public Health, Santa Ana hospital, Motril, and the Hospital del Mar d’Investigacions Mèdiques, Barcelona. According to the authors of the study «we are an example of clinical research focused on common diseases with a high impact on health».
Descargar

Researchers find exposure to pesticides in food, air and water increases risk of type 2 diabetes

Escrito por

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index. These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body. In a paper recently published in the journal Environmental Research, researchers demonstrate that people with higher concentrations of DDE –the main metabolite in the pesticide DDT– are four times more likely to develop type 2 diabetes than other people. In addition, the risk of type 2 diabetes is also associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano. A study with 386 subjects To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)». This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin. According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.» The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4% of the world population have this metabolic disorder. This will have a severe impact on public health programs, since it is highly resource-consuming. The factors causing such increase in the prevalence of diabetes are not still clearly understood. This research study was conducted by researchers at San Cecilio University Hospital, Granada, the University of Granada and the Andalusian School of Public Health, Santa Ana hospital, Motril, and the Hospital del Mar d’Investigacions Mèdiques, Barcelona. According to the authors of the study «we are an example of clinical research focused on common diseases with a high impact on health».
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Exercise beneficial for women with gestational diabetes

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Pregnant women who develop gestational diabetes mellitus (GDM) can reduce the adverse affects of the disease by regularly exercising during the second half of their pregnancy .

New research published in the British Journal of Sports Medicine shows that regular moderate-intensity exercise during the latter stages of pregnancy can improve foetal and maternal outcomes for women who develop GDM.

For the study, Jonatan Ruiz of the University of Granada, Spain, and colleagues assessed the benefits of moderate exercise three times a week from weeks 10-12 to weeks 38-39 of pregnancy compared to usual care for 510 women who were healthy and diabetes-free at the start of the research.

Just under a fifth of the exercise group developed GDM – based on World Health Organization (WHO) criteria – during their pregnancy, compared to 28 per cent of the control group.

While this difference was non-significant, the researchers found that the risk of macrosomia, a common foetal complication associated with gestational diabetes, was a statistically significant 58 per cent lower for GDM-affected women in the exercise group.

Exercising women who developed GDM also had a 1.76-fold increased risk for having a child with macrosomia – a condition linked with significant maternal and neonatal morbidity – compared with those without GDM. The elevated risk was considerably higher for women who received standard pregnancy care.

In addition, women with GDM in the exercise group were also a significant 34 per cent less likely than diabetes-free individuals in the same group to require an acute or elective cesarean delivery compared with the control group.

«Taken together, our findings provide further support for the benefits of moderate-intensity exercise, and for promoting supervised exercise interventions during pregnancy,» said Ruiz.

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Exercise beneficial for women with gestational diabetes

Escrito por

Pregnant women who develop gestational diabetes mellitus (GDM) can reduce the adverse affects of the disease by regularly exercising during the second half of their pregnancy .

New research published in the British Journal of Sports Medicine shows that regular moderate-intensity exercise during the latter stages of pregnancy can improve foetal and maternal outcomes for women who develop GDM.

For the study, Jonatan Ruiz of the University of Granada, Spain, and colleagues assessed the benefits of moderate exercise three times a week from weeks 10-12 to weeks 38-39 of pregnancy compared to usual care for 510 women who were healthy and diabetes-free at the start of the research.

Just under a fifth of the exercise group developed GDM – based on World Health Organization (WHO) criteria – during their pregnancy, compared to 28 per cent of the control group.

While this difference was non-significant, the researchers found that the risk of macrosomia, a common foetal complication associated with gestational diabetes, was a statistically significant 58 per cent lower for GDM-affected women in the exercise group.

Exercising women who developed GDM also had a 1.76-fold increased risk for having a child with macrosomia – a condition linked with significant maternal and neonatal morbidity – compared with those without GDM. The elevated risk was considerably higher for women who received standard pregnancy care.

In addition, women with GDM in the exercise group were also a significant 34 per cent less likely than diabetes-free individuals in the same group to require an acute or elective cesarean delivery compared with the control group.

«Taken together, our findings provide further support for the benefits of moderate-intensity exercise, and for promoting supervised exercise interventions during pregnancy,» said Ruiz.

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1 out of 4 lung cancer patients in Andalusia does not receive the radiotherapy they need

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A study conducted by University of Granada and Virgen de las Nieves U.H. researchers has revealed that in Andalusian public hospitals radiotherapy is provided to lung cancer patients with a frequency 25 % below that established by clinical protocols. Failure to provide such treatment results in a total of 3,000 survival-day loss for all lung cancer patients.
To carry out this study –recently published in the Journal of Thoracic Oncology–, the researchers reviewed the medical records and radiotherapy provided to all lung cancer patients in 2007 in the 12 Andalusian public hospitals fitted with radiotherapy facilities. Data were grouped by type of hospital, patient, type of treatment, histological type and tumor stage. This is very relevant, since other studies used aggregated data and interviews.
A Study with 3,051 Patients
Of the 3,051 lung cancer patients, 610 (radiation rate: 20 %) were initially treated with radiotherapy when according to the patients’ medical histories, the number of patients treated with radiotherapy should have been 1,383. Thus, 773 lung cancer patients (25%) did not receive the radiotherapy they needed.
According to the University of Granada professor José Expósito Hernández, radiotherapy is «crucial to the treatment of lung cancer and, according to the literature available, the percentage of patients that «must» receive radiotherapy can be established by the tumor stage, the histological type and other considerations». The studies conducted by the Canadian professor Mackillop –with whom the University of Granada researchers have worked– estimate the benefits of radiotherapy for each patient in terms of survival months
This article analyzes by regression tests the variables that influence the decision to provide or not radiotherapy to a patient. «Such decision may be based both, on equipment deficiencies (radiotherapy units and specialists) and on the specialist’s preferences», professor Hernandez states.
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1 out of 4 lung cancer patients in Andalusia does not receive the radiotherapy they need

Escrito por

A study conducted by University of Granada and Virgen de las Nieves U.H. researchers has revealed that in Andalusian public hospitals radiotherapy is provided to lung cancer patients with a frequency 25 % below that established by clinical protocols. Failure to provide such treatment results in a total of 3,000 survival-day loss for all lung cancer patients.
To carry out this study –recently published in the Journal of Thoracic Oncology–, the researchers reviewed the medical records and radiotherapy provided to all lung cancer patients in 2007 in the 12 Andalusian public hospitals fitted with radiotherapy facilities. Data were grouped by type of hospital, patient, type of treatment, histological type and tumor stage. This is very relevant, since other studies used aggregated data and interviews.
A Study with 3,051 Patients
Of the 3,051 lung cancer patients, 610 (radiation rate: 20 %) were initially treated with radiotherapy when according to the patients’ medical histories, the number of patients treated with radiotherapy should have been 1,383. Thus, 773 lung cancer patients (25%) did not receive the radiotherapy they needed.
According to the University of Granada professor José Expósito Hernández, radiotherapy is «crucial to the treatment of lung cancer and, according to the literature available, the percentage of patients that «must» receive radiotherapy can be established by the tumor stage, the histological type and other considerations». The studies conducted by the Canadian professor Mackillop –with whom the University of Granada researchers have worked– estimate the benefits of radiotherapy for each patient in terms of survival months
This article analyzes by regression tests the variables that influence the decision to provide or not radiotherapy to a patient. «Such decision may be based both, on equipment deficiencies (radiotherapy units and specialists) and on the specialist’s preferences», professor Hernandez states.
Descargar

1 out of 4 lung cancer patients in Andalusia does not receive the radiotherapy they need

Escrito por

A study conducted by University of Granada and Virgen de las Nieves U.H. researchers has revealed that in Andalusian public hospitals radiotherapy is provided to lung cancer patients with a frequency 25 % below that established by clinical protocols. Failure to provide such treatment results in a total of 3,000 survival-day loss for all lung cancer patients.

To carry out this study –recently published in the Journal of Thoracic Oncology–, the researchers reviewed the medical records and radiotherapy provided to all lung cancer patients in 2007 in the 12 Andalusian public hospitals fitted with radiotherapy facilities. Data were grouped by type of hospital, patient, type of treatment, histological type and tumor stage. This is very relevant, since other studies used aggregated data and interviews.

A Study with 3,051 Patients

Of the 3,051 lung cancer patients, 610 (radiation rate: 20 %) were initially treated with radiotherapy when according to the patients’ medical histories, the number of patients treated with radiotherapy should have been 1,383. Thus, 773 lung cancer patients (25%) did not receive the radiotherapy they needed.

According to the University of Granada professor José Expósito Hernández, radiotherapy is «crucial to the treatment of lung cancer and, according to the literature available, the percentage of patients that «must» receive radiotherapy can be established by the tumor stage, the histological type and other considerations». The studies conducted by the Canadian professor Mackillop –with whom the University of Granada researchers have worked– estimate the benefits of radiotherapy for each patient in terms of survival months

This article analyzes by regression tests the variables that influence the decision to provide or not radiotherapy to a patient. «Such decision may be based both, on equipment deficiencies (radiotherapy units and specialists) and on the specialist’s preferences», professor Hernandez states.

Descargar

1 out of 4 lung cancer patients in Andalusia does not receive the radiotherapy they need

Escrito por

A study conducted by University of Granada and Virgen de las Nieves U.H. researchers has revealed that in Andalusian public hospitals radiotherapy is provided to lung cancer patients with a frequency 25 % below that established by clinical protocols. Failure to provide such treatment results in a total of 3,000 survival-day loss for all lung cancer patients.

To carry out this study –recently published in the Journal of Thoracic Oncology–, the researchers reviewed the medical records and radiotherapy provided to all lung cancer patients in 2007 in the 12 Andalusian public hospitals fitted with radiotherapy facilities. Data were grouped by type of hospital, patient, type of treatment, histological type and tumor stage. This is very relevant, since other studies used aggregated data and interviews.

A Study with 3,051 Patients

Of the 3,051 lung cancer patients, 610 (radiation rate: 20 %) were initially treated with radiotherapy when according to the patients’ medical histories, the number of patients treated with radiotherapy should have been 1,383. Thus, 773 lung cancer patients (25%) did not receive the radiotherapy they needed.

According to the University of Granada professor José Expósito Hernández, radiotherapy is «crucial to the treatment of lung cancer and, according to the literature available, the percentage of patients that «must» receive radiotherapy can be established by the tumor stage, the histological type and other considerations». The studies conducted by the Canadian professor Mackillop –with whom the University of Granada researchers have worked– estimate the benefits of radiotherapy for each patient in terms of survival months

This article analyzes by regression tests the variables that influence the decision to provide or not radiotherapy to a patient. «Such decision may be based both, on equipment deficiencies (radiotherapy units and specialists) and on the specialist’s preferences», professor Hernandez states.

Descargar

Exposure to pesticides in food, air and water increases risk of type 2 diabetes

Escrito por

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index. These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body.

In a paper recently published in the journal Environmental Research, researchers demonstrate that people with higher concentrations of DDE –the main metabolite in the pesticide DDT– are four times more likely to develop type 2 diabetes than other people. In addition, the risk of type 2 diabetes is also associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.

A Study with 386 Subjects

To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)».

This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin.

According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.»

The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4% of the world population have this metabolic disorder. This will have a severe impact on public health programs, since it is highly resource-consuming. The factors causing such increase in the prevalence of diabetes are not still clearly understood.

This research study was conducted by researchers at San Cecilio University Hospital, Granada, the University of Granada and the Andalusian School of Public Health, Santa Ana hospital, Motril, and the Hospital del Mar d’Investigacions Mèdiques, Barcelona. According to the authors of the study «we are an example of clinical research focused on common diseases with a high impact on health».

Descargar