Study of a rare disease making people look like a woman but having male genitals under study

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University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.

 

AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor of androgens, and diagnosis is confirmed by the identification of such mutation. This disease is transmitted y a recessive gene associated to gender i.e. it is transmitted by women but it is only developed by men.

The researchers examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Diversity of Symptoms

Clinical symptoms of AIS range from spermatogenic defects causing infertility in men with otherwise normal genitalia, to subjects who look female in appearance but have not menstruation or female internal genitalia. Sometimes, the gender of IAS subjects cannot be identified at birth and a more precise diagnosis is required to determine the sex of the newborn and plan potential treatments.

According to one of the authors of the study, a researcher at the University of Granada Department of Obstetrics and Gynecology, therapy for AIS is based on three pillars:

«The first step is reinforcing the sexual identity of the subject with the help of psychologists. In cases of sexual ambiguity and determination of female gender, the second step is to perform a gonadectomy (removal of testicles), as they may become cancerous. Finally, it is necessary to administer hormone replacement therapy in case the subject is assigned the female sex. «The prognosis of these patients is good if the testicles are timely removed», professor Mendoza states.

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Exposure to pesticides raises diabetes risk

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Scientists have found that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index.

These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body. In a study conducted at the University of Granada, researchers demonstrate that people with higher concentrations of DDE –the main metabolite in the pesticide DDT– are four times more likely to develop type 2 diabetes than other people.

In addition, the risk of type 2 diabetes is also associated with exposure to beta-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.
To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain.

According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)».

This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics, which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin.

According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.»

The results were recently reported in the journal Environmental Research.

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Exposure to pesticides raises diabetes risk

Escrito por

Scientists have found that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index.

These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body. In a study conducted at the University of Granada, researchers demonstrate that people with higher concentrations of DDE –the main metabolite in the pesticide DDT– are four times more likely to develop type 2 diabetes than other people.

In addition, the risk of type 2 diabetes is also associated with exposure to beta-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.
To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain.

According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, «human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)».

This makes COPs concentrations a useful marker of a subject’s exposure to COPs. COPs are a group of chemicals with diverse characteristics, which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin.

According to professor Arrebola, «the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars.»

The results were recently reported in the journal Environmental Research.

Descargar

Study of a rare disease making people look like a woman but having male genitals

Escrito por

University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.
AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor of androgens, and diagnosis is confirmed by the identification of such mutation. This disease is transmitted y a recessive gene associated to gender i.e. it is transmitted by women but it is only developed by men.
The researchers examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.
Diversity of Symptoms
Clinical symptoms of AIS range from spermatogenic defects causing infertility in men with otherwise normal genitalia, to subjects who look female in appearance but have not menstruation or female internal genitalia. Sometimes, the gender of IAS subjects cannot be identified at birth and a more precise diagnosis is required to determine the sex of the newborn and plan potential treatments.
According to one of the authors of the study, a researcher at the University of Granada Department of Obstetrics and Gynecology, therapy for AIS is based on three pillars:
«The first step is reinforcing the sexual identity of the subject with the help of psychologists. In cases of sexual ambiguity and determination of female gender, the second step is to perform a gonadectomy (removal of testicles), as they may become cancerous. Finally, it is necessary to administer hormone replacement therapy in case the subject is assigned the female sex. «The prognosis of these patients is good if the testicles are timely removed», professor Mendoza states.
Provided by University of Granada
Descargar

Study of a rare disease making people look like a woman but having male genitals

Escrito por

University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.
AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor of androgens, and diagnosis is confirmed by the identification of such mutation. This disease is transmitted y a recessive gene associated to gender i.e. it is transmitted by women but it is only developed by men.
The researchers examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.
Diversity of Symptoms
Clinical symptoms of AIS range from spermatogenic defects causing infertility in men with otherwise normal genitalia, to subjects who look female in appearance but have not menstruation or female internal genitalia. Sometimes, the gender of IAS subjects cannot be identified at birth and a more precise diagnosis is required to determine the sex of the newborn and plan potential treatments.
According to one of the authors of the study, a researcher at the University of Granada Department of Obstetrics and Gynecology, therapy for AIS is based on three pillars:
«The first step is reinforcing the sexual identity of the subject with the help of psychologists. In cases of sexual ambiguity and determination of female gender, the second step is to perform a gonadectomy (removal of testicles), as they may become cancerous. Finally, it is necessary to administer hormone replacement therapy in case the subject is assigned the female sex. «The prognosis of these patients is good if the testicles are timely removed», professor Mendoza states.
Provided by University of Granada
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Scientists examine rare condition that makes people appear as women with male genitals

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t affects just one in 2000 people, but a team of researchers have developed guidelines for Androgen Insensitivity Syndrome (AIS).

University of Granada researchers have designed a guideline for physicians and patients on AIS, a rare disease that makes the individuals develop reverse sex — a subject that appears to look like a woman but has male genes.

According to researchers, a thorough study examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Descargar

Scientists examine rare condition that makes people appear as women with male genitals

Escrito por

t affects just one in 2000 people, but a team of researchers have developed guidelines for Androgen Insensitivity Syndrome (AIS).

University of Granada researchers have designed a guideline for physicians and patients on AIS, a rare disease that makes the individuals develop reverse sex — a subject that appears to look like a woman but has male genes.

According to researchers, a thorough study examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Descargar

Scientists examine rare condition that makes people appear as women with male genitals

Escrito por

t affects just one in 2000 people, but a team of researchers have developed guidelines for Androgen Insensitivity Syndrome (AIS).

University of Granada researchers have designed a guideline for physicians and patients on AIS, a rare disease that makes the individuals develop reverse sex — a subject that appears to look like a woman but has male genes.

According to researchers, a thorough study examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Descargar

Link found between pesticides and type-2 diabetes

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Pesticides in food, air and water may be directly linked with the development of type 2 diabetes, regardless of a person’s age, gender or body mass index, a new Spanish research study has found.
These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the greater the fat, the higher the pesticide concentrations in the body, researchers from the University of Granada found.
Researchers demonstrate that people with higher concentrations of DDE – the main metabolite in the pesticide DDT – are four times more likely to develop type 2 diabetes than other people, the journal Environmental Research reports.
In addition, the risk of type 2 diabetes is also associated with exposure to I-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano, according to a Granada statement.
Researchers analyzed concentrations of a specific group of pesticides in the adipose tissue of 386 adult subjects at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain.
Granada researcher Juan Pedro Arrebola said: «Human adipose tissue (fat) acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs-pesticides).»
COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building material. These compounds penetrate the body mainly through food, but also through air or the skin.
The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4 percent of the world population will live with this metabolic disorder.
Descargar

Link found between pesticides and type-2 diabetes

Escrito por

Pesticides in food, air and water may be directly linked with the development of type 2 diabetes, regardless of a person’s age, gender or body mass index, a new Spanish research study has found.
These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the greater the fat, the higher the pesticide concentrations in the body, researchers from the University of Granada found.
Researchers demonstrate that people with higher concentrations of DDE – the main metabolite in the pesticide DDT – are four times more likely to develop type 2 diabetes than other people, the journal Environmental Research reports.
In addition, the risk of type 2 diabetes is also associated with exposure to I-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano, according to a Granada statement.
Researchers analyzed concentrations of a specific group of pesticides in the adipose tissue of 386 adult subjects at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain.
Granada researcher Juan Pedro Arrebola said: «Human adipose tissue (fat) acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs-pesticides).»
COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building material. These compounds penetrate the body mainly through food, but also through air or the skin.
The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4 percent of the world population will live with this metabolic disorder.
Descargar

Link found between pesticides and type-2 diabetes

Escrito por

Pesticides in food, air and water may be directly linked with the development of type 2 diabetes, regardless of a person’s age, gender or body mass index, a new Spanish research study has found.
These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the greater the fat, the higher the pesticide concentrations in the body, researchers from the University of Granada found.
Researchers demonstrate that people with higher concentrations of DDE – the main metabolite in the pesticide DDT – are four times more likely to develop type 2 diabetes than other people, the journal Environmental Research reports.
In addition, the risk of type 2 diabetes is also associated with exposure to I-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano, according to a Granada statement.
Researchers analyzed concentrations of a specific group of pesticides in the adipose tissue of 386 adult subjects at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain.
Granada researcher Juan Pedro Arrebola said: «Human adipose tissue (fat) acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs-pesticides).»
COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building material. These compounds penetrate the body mainly through food, but also through air or the skin.
The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4 percent of the world population will live with this metabolic disorder.
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Exposure To Pesticides In Food, Water Ups Diabetes Risk

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GRANADA, Spain—A person’s exposure to pesticides in food, air and water has a direct relationship with the prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index, according to a new study published in the journal Environmental Research.

The findings suggest substances (persistent organic pollutants or COPs) found in pesticides tend to concentrate in body fat, and may be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body.

Researchers at the University of Granada found people with higher concentrations of DDE—the main metabolite in the pesticide DDT—are four times more likely to develop type 2 diabetes than other people. The risk of type 2 diabetes also is associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.

Researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at two hospitals in Spain. They said human adipose tissue acts as an energy reservoir and has an important metabolic function; however, it can store potentially harmful substances, such as COPs. This makes COPs concentrations a useful marker of a subject’s exposure to COPs, which are a group of chemicals with diverse characteristics that are present in pesticides, industrial waste and building materials. The compounds penetrate the body mainly through food, but also through air or the skin.

«The mechanism of action by which COPs increase the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars,» the researchers said.

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