Link found between pesticides and type-2 diabetes

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Pesticides in food, air and water may be directly linked with the development of type 2 diabetes, regardless of a person’s age, gender or body mass index, a new Spanish research study has found.

These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the greater the fat, the higher the pesticide concentrations in the body, researchers from the University of Granada found.

Researchers demonstrate that people with higher concentrations of DDE – the main metabolite in the pesticide DDT – are four times more likely to develop type 2 diabetes than other people, the journal Environmental Research reports.

In addition, the risk of type 2 diabetes is also associated with exposure to I-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano, according to a Granada statement.

Researchers analyzed concentrations of a specific group of pesticides in the adipose tissue of 386 adult subjects at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain.

Granada researcher Juan Pedro Arrebola said: «Human adipose tissue (fat) acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs-pesticides).»

COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building material. These compounds penetrate the body mainly through food, but also through air or the skin.

The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4 percent of the world population will live with this metabolic disorder.

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Why are obese people at risk of type-2 diabetes?

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Regardless of a person’s age, gender or body mass index, pesticides in food, air and water may be directly linked with the development of type 2 diabetes, a new Spanish research study has found.
These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the greater the fat, the higher the pesticide concentrations in the body, researchers from the University of Granada found. Researchers demonstrate that people with higher concentrations of DDE – the main metabolite in the pesticide DDT – are four times more likely to develop type 2 diabetes than other people, the journal Environmental Research reports. In addition, the risk of type 2 diabetes is also associated with exposure to I-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano, according to a Granada statement.
Researchers analyzed concentrations of a specific group of pesticides in the adipose tissue of 386 adult subjects at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. Granada researcher Juan Pedro Arrebola said: ‘Human adipose tissue (fat) acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (POPs-pesticides).’ POPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building material. These compounds penetrate the body mainly through food, but also through air or the skin.
The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4 percent of the world population will live with this metabolic disorder.
Descargar

Why are obese people at risk of type-2 diabetes?

Escrito por

Regardless of a person’s age, gender or body mass index, pesticides in food, air and water may be directly linked with the development of type 2 diabetes, a new Spanish research study has found.
These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the greater the fat, the higher the pesticide concentrations in the body, researchers from the University of Granada found. Researchers demonstrate that people with higher concentrations of DDE – the main metabolite in the pesticide DDT – are four times more likely to develop type 2 diabetes than other people, the journal Environmental Research reports. In addition, the risk of type 2 diabetes is also associated with exposure to I-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano, according to a Granada statement.
Researchers analyzed concentrations of a specific group of pesticides in the adipose tissue of 386 adult subjects at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. Granada researcher Juan Pedro Arrebola said: ‘Human adipose tissue (fat) acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (POPs-pesticides).’ POPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building material. These compounds penetrate the body mainly through food, but also through air or the skin.
The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4 percent of the world population will live with this metabolic disorder.
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Air, Water and Food Pollution Linked to Diabetes Risk

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Genetics, sedentary lifestyle and eating habits are all well-known risk factors for diabetes type-2. A new study, however, says that there may be other factors that go unnoticed, like the pesticides present in the food, water and air that may increase the chances of being diagnosed with diabetes type-2.
According to researchers from the University of Granada, exposure to these pesticides or Persistent Organic Pollutants, or COPs in the environment raises the risk of diabetes independent of age, sex or body mass index of the person.

The research even explains why obese people are more likely to suffer from diabetes. They say that the higher the fat content in the body, the more pesticide is stored in the body, which increases the risk of diabetes type-2.
«Human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs),» said Juan Pedro Arrebola, researcher from University of Granada in a news release.
The study was based on more than 380 participants. Researchers assessed the test subjects’ levels of pesticide exposure. Study results showed that people with high concentration of DDE present in pesticide DDT were at least four times more likely to be diagnosed with diabetes type-2. Also, β-HCH (beta-Hexachlorocyclohexane), was seen as increasing the risk for the condition.
Both DDT and β-HCH (beta-Hexachlorocyclohexane) were banned in the U.S. during the 1970s. However, some people still have measurable amounts of DDE in them as this chemical takes longer to break down, according to Centers for Disease Control and Prevention (CDC). β-HCH (beta-Hexachlorocyclohexane) has previously been linked to increase in risk of Parkinson’s Disease.
Although pesticides studied in the present research aren’t used in the U.S., they – especially DDT – are widely used in other countries in agriculture and to fight mosquitoes. Experts have earlier warned against the use of DDT.
The study is published in the journal Environmental Research.
In the U.S., the number of people being diagnosed with diabetes has tripled from 5.6 million in 1980 to 26.9 million in 2010. At present, the U.S. economy pumps in $117 billion dollars for the treatment of diabetes each year. According to CDC, by 2050, 1 in 3 U.S. adults will have diabetes. The condition is the leading cause of blindness, kidney failure and limb amputations not caused by an accident.
According to estimates by WHO, the number of people with diabetes is expected to increase from 170 million today to about 370 million in 2030, and a large number of the cases will be reported in the developing countries.
Researchers from the present study say that the pesticides may be affecting the way sugars are broken down in the body. However, they maintain that they can’t pinpoint how the pesticides cause these changes.
«The mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars,» added Arrebola, according to the news release.

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Air, Water and Food Pollution Linked to Diabetes Risk

Escrito por

Genetics, sedentary lifestyle and eating habits are all well-known risk factors for diabetes type-2. A new study, however, says that there may be other factors that go unnoticed, like the pesticides present in the food, water and air that may increase the chances of being diagnosed with diabetes type-2.
According to researchers from the University of Granada, exposure to these pesticides or Persistent Organic Pollutants, or COPs in the environment raises the risk of diabetes independent of age, sex or body mass index of the person.

The research even explains why obese people are more likely to suffer from diabetes. They say that the higher the fat content in the body, the more pesticide is stored in the body, which increases the risk of diabetes type-2.
«Human adipose tissue (commonly known as «fat») acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs),» said Juan Pedro Arrebola, researcher from University of Granada in a news release.
The study was based on more than 380 participants. Researchers assessed the test subjects’ levels of pesticide exposure. Study results showed that people with high concentration of DDE present in pesticide DDT were at least four times more likely to be diagnosed with diabetes type-2. Also, β-HCH (beta-Hexachlorocyclohexane), was seen as increasing the risk for the condition.
Both DDT and β-HCH (beta-Hexachlorocyclohexane) were banned in the U.S. during the 1970s. However, some people still have measurable amounts of DDE in them as this chemical takes longer to break down, according to Centers for Disease Control and Prevention (CDC). β-HCH (beta-Hexachlorocyclohexane) has previously been linked to increase in risk of Parkinson’s Disease.
Although pesticides studied in the present research aren’t used in the U.S., they – especially DDT – are widely used in other countries in agriculture and to fight mosquitoes. Experts have earlier warned against the use of DDT.
The study is published in the journal Environmental Research.
In the U.S., the number of people being diagnosed with diabetes has tripled from 5.6 million in 1980 to 26.9 million in 2010. At present, the U.S. economy pumps in $117 billion dollars for the treatment of diabetes each year. According to CDC, by 2050, 1 in 3 U.S. adults will have diabetes. The condition is the leading cause of blindness, kidney failure and limb amputations not caused by an accident.
According to estimates by WHO, the number of people with diabetes is expected to increase from 170 million today to about 370 million in 2030, and a large number of the cases will be reported in the developing countries.
Researchers from the present study say that the pesticides may be affecting the way sugars are broken down in the body. However, they maintain that they can’t pinpoint how the pesticides cause these changes.
«The mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars,» added Arrebola, according to the news release.

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Pesticides in Food increases risk of Type 2 Diabetes

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According to the results of a new study that has been conducted by researchers at the University of Granada, pesticides found in food, air and water can significantly increase the chances of developing Type 2 Diabetes .

Adipose tissue or more commonly known as fat has an important role in the body acting as an energy store with critical metabolism functions. However fat cells can also store potentially toxic substances that can damage the body such as persistent organic pollutants (POP) or pesticides. These pollutants are not easily broken down and are subsequently found in the food chain, water, air and stored in animal and human cells.

Previous research has shown that these persistent pollutants could increase the risk of cancer. This latest research has found that their presence in fat tissue in the human body is correlated with the development with type 2 diabetes.

Samples of fat tissue were taken from 386 Spanish adults. The concentration of 6 major groups of pesticides was established and examined alongside life style factors such as dietary habits and health statuses.

The researchers found that those individuals who were overweight or obese had higher levels of pesticide in their fat cells. This increase in pesticide concentration was linked to a higher incidence of Type 2 Diabetes. This direct relationship between high levels of pollutants was found irrespective of age, gender or BMI.

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Pesticides in Food increases risk of Type 2 Diabetes

Escrito por

According to the results of a new study that has been conducted by researchers at the University of Granada, pesticides found in food, air and water can significantly increase the chances of developing Type 2 Diabetes .

Adipose tissue or more commonly known as fat has an important role in the body acting as an energy store with critical metabolism functions. However fat cells can also store potentially toxic substances that can damage the body such as persistent organic pollutants (POP) or pesticides. These pollutants are not easily broken down and are subsequently found in the food chain, water, air and stored in animal and human cells.

Previous research has shown that these persistent pollutants could increase the risk of cancer. This latest research has found that their presence in fat tissue in the human body is correlated with the development with type 2 diabetes.

Samples of fat tissue were taken from 386 Spanish adults. The concentration of 6 major groups of pesticides was established and examined alongside life style factors such as dietary habits and health statuses.

The researchers found that those individuals who were overweight or obese had higher levels of pesticide in their fat cells. This increase in pesticide concentration was linked to a higher incidence of Type 2 Diabetes. This direct relationship between high levels of pollutants was found irrespective of age, gender or BMI.

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Spanish researchers design biomarkers for the detection of dengue and West Nile virus

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This shows electrophoresis of DNA observed under ultraviolet light. Credit: Rekom Biotech – University of Granada Researchers at the University of Granada have designed a set of biomarkers that can be used in diagnostic tests for the detection of dengue and the West Nile virus, two infectious diseases transmitted by the bite of a mosquito. These biomarkers can be used to identify these viral diseases, which affect millions of people worldwide. Ads by Google Ahorra – ¿Todavía no has probado Danacol? Descárgate aquí cupones descuento – www.gananones.es The University of Granada spin-off Rekom Biotech is a biotech company composed of professionals from the private sector and from the University of Granada. Rekom Biotech is focused in the design and production of biological material used in diagnostic tests called «recombinant antigents». These antigens are markers of a variety of diseases caused by viruses, bacteria, fungi and parasites. Saving Lives and Money These products can be used in the different in vitro diagnostic platforms or systems. Specifically, the biomarkers designed at the University of Granada spin off «might serve to design diagnostic tests that will help save lives and money», states the Rekom Biotech general manager, Ana Camacho Páez. The Andalusian company also supplies other services based on the design and production of proteins and other molecular biology tools. Currently, Rekom Biotech supplies white label recombinant antigens to two American companies, and will start supplying biological material to a German company soon. Their catalogue includes more than 50 recombinant antigens for the in vitro diagnosis of a range of infectious diseases. This company conducts its R&D activities at the Health Technology Park in Granada, Spain. Provided by University of Granada

Read more at: http://medicalxpress.com/news/2013-02-spanish-biomarkers-dengue-west-nile.html#jCp

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Spanish researchers design biomarkers for the detection of dengue and West Nile virus

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This shows electrophoresis of DNA observed under ultraviolet light. Credit: Rekom Biotech – University of Granada Researchers at the University of Granada have designed a set of biomarkers that can be used in diagnostic tests for the detection of dengue and the West Nile virus, two infectious diseases transmitted by the bite of a mosquito. These biomarkers can be used to identify these viral diseases, which affect millions of people worldwide. Ads by Google Ahorra – ¿Todavía no has probado Danacol? Descárgate aquí cupones descuento – www.gananones.es The University of Granada spin-off Rekom Biotech is a biotech company composed of professionals from the private sector and from the University of Granada. Rekom Biotech is focused in the design and production of biological material used in diagnostic tests called «recombinant antigents». These antigens are markers of a variety of diseases caused by viruses, bacteria, fungi and parasites. Saving Lives and Money These products can be used in the different in vitro diagnostic platforms or systems. Specifically, the biomarkers designed at the University of Granada spin off «might serve to design diagnostic tests that will help save lives and money», states the Rekom Biotech general manager, Ana Camacho Páez. The Andalusian company also supplies other services based on the design and production of proteins and other molecular biology tools. Currently, Rekom Biotech supplies white label recombinant antigens to two American companies, and will start supplying biological material to a German company soon. Their catalogue includes more than 50 recombinant antigens for the in vitro diagnosis of a range of infectious diseases. This company conducts its R&D activities at the Health Technology Park in Granada, Spain. Provided by University of Granada

Read more at: http://medicalxpress.com/news/2013-02-spanish-biomarkers-dengue-west-nile.html#jCp

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RARE DISEASE MAKES PEOPLE LOOK LIKE A WOMAN, WITH MALE GENITALS

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University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.

 

AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor of androgens, and diagnosis is confirmed by the identification of such mutation. This disease is transmitted y a recessive gene associated to gender i.e. it is transmitted by women but it is only developed by men.

The researchers examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Diversity of Symptoms

Clinical symptoms of AIS range from spermatogenic defects causing infertility in men with otherwise normal genitalia, to subjects who look female in appearance but have not menstruation or female internal genitalia. Sometimes, the gender of IAS subjects cannot be identified at birth and a more precise diagnosis is required to determine the sex of the newborn and plan potential treatments.

According to one of the authors of the study, a researcher at the University of Granada Department of Obstetrics and Gynecology, therapy for AIS is based on three pillars:

«The first step is reinforcing the sexual identity of the subject with the help of psychologists. In cases of sexual ambiguity and determination of female gender, the second step is to perform a gonadectomy (removal of testicles), as they may become cancerous. Finally, it is necessary to administer hormone replacement therapy in case the subject is assigned the female sex. «The prognosis of these patients is good if the testicles are timely removed», professor Mendoza states.

The Androgen Insensitivity Syndrome Guideline for physicians and patients is available at the web site of the Biomedical Research Network of Rare Diseases (CIBERER) www.ciberer.es, the Spanish Association of Human Genetics www.aegh.org and the research group on cancer in patients with polymalformation genetic syndromes (www.ct-csgp.org).

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RARE DISEASE MAKES PEOPLE LOOK LIKE A WOMAN, WITH MALE GENITALS

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University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.

 

AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor of androgens, and diagnosis is confirmed by the identification of such mutation. This disease is transmitted y a recessive gene associated to gender i.e. it is transmitted by women but it is only developed by men.

The researchers examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Diversity of Symptoms

Clinical symptoms of AIS range from spermatogenic defects causing infertility in men with otherwise normal genitalia, to subjects who look female in appearance but have not menstruation or female internal genitalia. Sometimes, the gender of IAS subjects cannot be identified at birth and a more precise diagnosis is required to determine the sex of the newborn and plan potential treatments.

According to one of the authors of the study, a researcher at the University of Granada Department of Obstetrics and Gynecology, therapy for AIS is based on three pillars:

«The first step is reinforcing the sexual identity of the subject with the help of psychologists. In cases of sexual ambiguity and determination of female gender, the second step is to perform a gonadectomy (removal of testicles), as they may become cancerous. Finally, it is necessary to administer hormone replacement therapy in case the subject is assigned the female sex. «The prognosis of these patients is good if the testicles are timely removed», professor Mendoza states.

The Androgen Insensitivity Syndrome Guideline for physicians and patients is available at the web site of the Biomedical Research Network of Rare Diseases (CIBERER) www.ciberer.es, the Spanish Association of Human Genetics www.aegh.org and the research group on cancer in patients with polymalformation genetic syndromes (www.ct-csgp.org).

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Study of a rare disease making people look like a woman but having male genitals under study

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University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.

 

AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor of androgens, and diagnosis is confirmed by the identification of such mutation. This disease is transmitted y a recessive gene associated to gender i.e. it is transmitted by women but it is only developed by men.

The researchers examined the most relevant clinical and epidemiological data of AIS in a review study recently published in the journal Gynecological Endocrinology. The guideline for patients includes the follow-up protocols to be applied from birth to adulthood, through childhood and adolescence. The guideline also includes additional information for patients.

Diversity of Symptoms

Clinical symptoms of AIS range from spermatogenic defects causing infertility in men with otherwise normal genitalia, to subjects who look female in appearance but have not menstruation or female internal genitalia. Sometimes, the gender of IAS subjects cannot be identified at birth and a more precise diagnosis is required to determine the sex of the newborn and plan potential treatments.

According to one of the authors of the study, a researcher at the University of Granada Department of Obstetrics and Gynecology, therapy for AIS is based on three pillars:

«The first step is reinforcing the sexual identity of the subject with the help of psychologists. In cases of sexual ambiguity and determination of female gender, the second step is to perform a gonadectomy (removal of testicles), as they may become cancerous. Finally, it is necessary to administer hormone replacement therapy in case the subject is assigned the female sex. «The prognosis of these patients is good if the testicles are timely removed», professor Mendoza states.

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