(+)-Myrrhanol C made

Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C.

(+)-Myrrhanol C is a natural triterpene isolated from mastic gum (the resin of Pistacia lentiscus), a substance well known for its medicinal properties as well as use in various cuisines. The compound itself was used to embalm corpses in ancient Egypt. More recently, it has been recognised as a promising anti-prostate cancer lead. However, before a molecule can be used to develop drugs, a successful synthesis must be developed.

Mastic gum (from Pistacia lentiscus, pictured) has been used for many applications, from treating snakebites to tooth whiteners. © Science Photo Library
Alejandro Barrero and his group at the University of Granada have done just that. Their synthesis starts with (–)-sclareol, a bicyclic diterpene alcohol isolated from clary sage (Salvia sclarea). It then proceeds through a key C–H oxidation step, which is achieved with cytochrome P450 enzyme catalysis by incubating a reaction intermediate with the fungus Mucor plumbeus.

By cultivating clary sage, Barrero can sustainably produce (–)-sclareol, meaning (+)-myrrhanol C can be made on a large scale that is also environmentally friendly.

However, the use of natural products and processes in the synthesis also gives another important benefit to the synthetic strategy. ‘Apart from using a natural chiral synthon as starting material, the only process generating a new chiral centre is the microbial hydroxylation,’ explains Barrero. This means the researchers could carefully control the stereochemistry of the synthetic product, which could be very important for clinical applications. ‘The selectivity [for the (+) isomer] of our synthesis is total,’ he concludes.

Bob Hill, a natural products expert at the University of Glasgow, welcomes the synthesis of (+)-myrrhanol C even though he is not enthused by the chemistry. ‘They seem to have produced a reasonably good synthesis (using established methodology) to a potentially useful compound,’ he says.

Barrero says that the next step is to investigate synthetic analogues and their antitumour activity with a view to drug discovery.

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Teenagers Need Exercise To Build Strong Bones

Sedentary teenagers are at an increased risk for low bone-mineral density and developing osteoporosis later in life, according to a new study published in PubMed.

Researchers studied both adolescent boys and girls and found that different sedentary activities put them at the greatest risk for thin bones. Studying put girls at the greatest risk for low bone density, while boys were at the greatest risk because of leisure Internet use. Girls bone density could be improved by participating in a minimum of three hours of sports, such as football, basketball, netball, or running.

Dr. Luis Gracia Marco of the University of Exeter explained that girls still need to study, but their research has demonstrated the effects that sedentary behavior has on bone health.

Marco studied 359 Spanish adolescents who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Scientists from University of Zaragoza, the University of Granada, the Spanish National Research Council (CSIC), and the University of São Paulo, Brazil worked together on this study.

The femoral neck region of the hip was measured for bone mineral density. This area is important for determining signs of osteoporosis. The researchers compared the activities of sitting, watching TV, or playing computer games to see if there was an association with low bone mineral content.

The researchers found that girls who were sitting at a desk had an associated risk. They found that the girls who spent at least three hours a week in upright high-intensity sports were at a significantly reduced risk for low bone density. In the adolescent boys, those who spent the most time on Internet leisure activities were at a higher risk for reduced bone mineral content through the whole body.

Dr. Marco said that more research is needed to determine why boys and girls differed in how the low bone density occurred.

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Teenagers Need Exercise To Build Strong Bones

Sedentary teenagers are at an increased risk for low bone-mineral density and developing osteoporosis later in life, according to a new study published in PubMed.

Researchers studied both adolescent boys and girls and found that different sedentary activities put them at the greatest risk for thin bones. Studying put girls at the greatest risk for low bone density, while boys were at the greatest risk because of leisure Internet use. Girls bone density could be improved by participating in a minimum of three hours of sports, such as football, basketball, netball, or running.

Dr. Luis Gracia Marco of the University of Exeter explained that girls still need to study, but their research has demonstrated the effects that sedentary behavior has on bone health.

Marco studied 359 Spanish adolescents who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Scientists from University of Zaragoza, the University of Granada, the Spanish National Research Council (CSIC), and the University of São Paulo, Brazil worked together on this study.

The femoral neck region of the hip was measured for bone mineral density. This area is important for determining signs of osteoporosis. The researchers compared the activities of sitting, watching TV, or playing computer games to see if there was an association with low bone mineral content.

The researchers found that girls who were sitting at a desk had an associated risk. They found that the girls who spent at least three hours a week in upright high-intensity sports were at a significantly reduced risk for low bone density. In the adolescent boys, those who spent the most time on Internet leisure activities were at a higher risk for reduced bone mineral content through the whole body.

Dr. Marco said that more research is needed to determine why boys and girls differed in how the low bone density occurred.

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Exercise could help ward off bone disease in teens

Teenagers have been urged to play sports or run for at least three hours a week to counteract the potential damage to their bone health caused by prolonged spells of sitting.

An international team, including an expert from the University of Exeter, has found evidence that adolescents who spend long periods engaged in certain sedentary activities are more likely to have low bone mineral content in parts of the body where it can be an indicator of the risk of developing osteoporosis.

In the research, the team found that studying put girls at particular risk, while for boys leisure internet use posed the greatest threat.

Scientists found that participating in at least three hours of certain sports could significantly reduce the threat in girls. The study found evidence of the benefits of high-intensity sports where the participant is on their feet, such as football, basketball, netball or running.

Scientists have previously studied the impact of an inactive lifestyle on problems such as obesity or heart defects, but this is one of the first studies analysing the effects of different sedentary behaviours on bone health in the critical development period of adolescence.

«Clearly we are not telling girls not to study. It is a fact of modern life that teenagers spend more time engaged in deskbound or sitting activities, but our research is one of the first to identify a connection between this behaviour in adolescents and low levels of bone mass in key regions of the body,» said Dr Luis Gracia Marco of the University of Exeter, who led the research.

«It is already well-known that an inactive lifestyle has implications for young people, such as obesity and heart diseases. Combined with that, our findings emphasise the need for exercise, and we hope it will give some focus for young people and their parents to ward off any health problems later in life,» Dr Marco added.

The research was carried out in collaboration with scientists from the University of Zaragoza, the University of Granada, the Spanish National Research Council (CSIC), and the University of Sao Paulo, Brazil. It was supported by the European community Sixth RTD Framework Program, as well as with a grant from Fundacion Cuenca Villoro.

The research assessed the lifestyles of 359 Spanish adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. It examined bone mineral content in the femoral neck region of the hip, which is a critical area for diagnosing osteoporosis.

The research team looked at the impact of different types of sitting activity, including watching television and playing computer games. The strongest connection between deskbound behaviour and low bone mineral content was found in girls’ hips, which is where most fractures occur. It was linked to study time, but regardless of how much time they spent studying, the risk was significantly reduced if they spent at least three hours each week participating in high-intensity upright sport.

Internet leisure use was found to negatively affect whole body bone mineral content in boys.

Dr Gracia Marco said: «More research is needed to establish exactly why there are differences between the two genders, and why these types of activity are particularly damageing to teenage boys and girls, but we can speculate that it is linked to how long they remain in the same position.

The research was published in PubMed.

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Exercise could help ward off bone disease in teens

Teenagers have been urged to play sports or run for at least three hours a week to counteract the potential damage to their bone health caused by prolonged spells of sitting.

An international team, including an expert from the University of Exeter, has found evidence that adolescents who spend long periods engaged in certain sedentary activities are more likely to have low bone mineral content in parts of the body where it can be an indicator of the risk of developing osteoporosis.

In the research, the team found that studying put girls at particular risk, while for boys leisure internet use posed the greatest threat.

Scientists found that participating in at least three hours of certain sports could significantly reduce the threat in girls. The study found evidence of the benefits of high-intensity sports where the participant is on their feet, such as football, basketball, netball or running.

Scientists have previously studied the impact of an inactive lifestyle on problems such as obesity or heart defects, but this is one of the first studies analysing the effects of different sedentary behaviours on bone health in the critical development period of adolescence.

«Clearly we are not telling girls not to study. It is a fact of modern life that teenagers spend more time engaged in deskbound or sitting activities, but our research is one of the first to identify a connection between this behaviour in adolescents and low levels of bone mass in key regions of the body,» said Dr Luis Gracia Marco of the University of Exeter, who led the research.

«It is already well-known that an inactive lifestyle has implications for young people, such as obesity and heart diseases. Combined with that, our findings emphasise the need for exercise, and we hope it will give some focus for young people and their parents to ward off any health problems later in life,» Dr Marco added.

The research was carried out in collaboration with scientists from the University of Zaragoza, the University of Granada, the Spanish National Research Council (CSIC), and the University of Sao Paulo, Brazil. It was supported by the European community Sixth RTD Framework Program, as well as with a grant from Fundacion Cuenca Villoro.

The research assessed the lifestyles of 359 Spanish adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. It examined bone mineral content in the femoral neck region of the hip, which is a critical area for diagnosing osteoporosis.

The research team looked at the impact of different types of sitting activity, including watching television and playing computer games. The strongest connection between deskbound behaviour and low bone mineral content was found in girls’ hips, which is where most fractures occur. It was linked to study time, but regardless of how much time they spent studying, the risk was significantly reduced if they spent at least three hours each week participating in high-intensity upright sport.

Internet leisure use was found to negatively affect whole body bone mineral content in boys.

Dr Gracia Marco said: «More research is needed to establish exactly why there are differences between the two genders, and why these types of activity are particularly damageing to teenage boys and girls, but we can speculate that it is linked to how long they remain in the same position.

The research was published in PubMed.

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Con la sansa d’oliva è possibile una funghicoltura da reddito

Una spin off dell’Università di Granada ha brevettato un sistema per rendere il sottoprodotto oleario un perfetto substrato per far crescere funghi anche ad alto valore aggiunto
Una spin off dell’Università di Granada (Misur) ha brevettato il metodo di produzione e il substrato, a base di sansa d’oliva, per la coltivazione sia dei comuni funghi shiitake sia dei più pregiati delicious.
Il metodo di produzione si basa su una miscela, a base di sansa d’oliva, miscelata con residui vegetali, generalmente di mais, fertilizzanti biologici e miceli di funghi.
Ne esce così un substrato perfetto per una funghicoltura da reddito.
Il prodotto così ottenuto ha infatti notevoli vantaggi. Oltre ad essere 100% organic, e quindi utilizzabile in regime biologico, presenta un metodo innovativo di gestire il sottoprodotto sansa e quello del mais, valorizzandone le caratteristiche.
In particolare, riguardo alla sansa, avrebbe proprietà nutrienti, visto il contenuto d’azoto, ma anche antifungine, visto l’alto tenore di polifenoli. Sarebbe un controsenso utilizzare antifungini in un substrato per la funghicoltura, se non fosse che la nascita di funghi diversi da quelli voluti, esattamente come avviene per le infestanti, può far diminuire la redditività della coltura. Inoltre i polifenoli agiscono da antiossidanti naturali, proteggendo i miceli dall’aggressione di patogeni.
Uno dei segreti del successo dell’iniziativa è infatti quello di inoculare il substrato a base di sansa non con le spore, che potrebbero essere danneggiate irreparabilmente dall’azione antifungina dei polifenoli, ma dei miceli. «facendo un confronto con gli alberi da frutto, sarebbe come piantare una piccola mela» ci spiega il direttore del Misur Alberto Lamenca.
Nel mix del substrato, come fertilizzanti naturali e regolatori dell’acidità, vengono anche utilizzate le vinacce.
Il substrato preparato da Misur è attualmente venduto in tutto in diverse regioni spagnole: in tutta la provincia di Granada, da Guadix, dove è situato l’impianto di produzione, a nord (Baza, Huéscar), fino alla regione di Alhama. E’ già prevista un’espansione dei punti vendita a Alpujarra in Andalusia, a Capra in provincia di Cordoba, a Sierra de Ronda nell’area di Malaga e a Sierra Norte in provincia di Siviglia.
Attualmente l’impianto di produzione utilizza 300 tonnellate all’anno di sansa.
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Con la sansa d’oliva è possibile una funghicoltura da reddito

Una spin off dell’Università di Granada ha brevettato un sistema per rendere il sottoprodotto oleario un perfetto substrato per far crescere funghi anche ad alto valore aggiunto
Una spin off dell’Università di Granada (Misur) ha brevettato il metodo di produzione e il substrato, a base di sansa d’oliva, per la coltivazione sia dei comuni funghi shiitake sia dei più pregiati delicious.
Il metodo di produzione si basa su una miscela, a base di sansa d’oliva, miscelata con residui vegetali, generalmente di mais, fertilizzanti biologici e miceli di funghi.
Ne esce così un substrato perfetto per una funghicoltura da reddito.
Il prodotto così ottenuto ha infatti notevoli vantaggi. Oltre ad essere 100% organic, e quindi utilizzabile in regime biologico, presenta un metodo innovativo di gestire il sottoprodotto sansa e quello del mais, valorizzandone le caratteristiche.
In particolare, riguardo alla sansa, avrebbe proprietà nutrienti, visto il contenuto d’azoto, ma anche antifungine, visto l’alto tenore di polifenoli. Sarebbe un controsenso utilizzare antifungini in un substrato per la funghicoltura, se non fosse che la nascita di funghi diversi da quelli voluti, esattamente come avviene per le infestanti, può far diminuire la redditività della coltura. Inoltre i polifenoli agiscono da antiossidanti naturali, proteggendo i miceli dall’aggressione di patogeni.
Uno dei segreti del successo dell’iniziativa è infatti quello di inoculare il substrato a base di sansa non con le spore, che potrebbero essere danneggiate irreparabilmente dall’azione antifungina dei polifenoli, ma dei miceli. «facendo un confronto con gli alberi da frutto, sarebbe come piantare una piccola mela» ci spiega il direttore del Misur Alberto Lamenca.
Nel mix del substrato, come fertilizzanti naturali e regolatori dell’acidità, vengono anche utilizzate le vinacce.
Il substrato preparato da Misur è attualmente venduto in tutto in diverse regioni spagnole: in tutta la provincia di Granada, da Guadix, dove è situato l’impianto di produzione, a nord (Baza, Huéscar), fino alla regione di Alhama. E’ già prevista un’espansione dei punti vendita a Alpujarra in Andalusia, a Capra in provincia di Cordoba, a Sierra de Ronda nell’area di Malaga e a Sierra Norte in provincia di Siviglia.
Attualmente l’impianto di produzione utilizza 300 tonnellate all’anno di sansa.
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Melilla conBici y el Cicode trabajan en un seminario que aborda la infancia y el urbanismo

El Centro de Iniciativas de Cooperación al Desarrollo (Cicode) y Melilla conBici están trabajando desde hace varias semanas en la realización de un Seminario sobre Urbanismo e Infancia que tendrá lugar entre los días 18 y 23 de febrero de 2013 y que contará con la presencia destacada de Francesco Tonucci, uno de los pedagogos más influyentes de las últimas décadas y creador del proyecto internacional ‘La ciudad de los niños y niñas’. La iniciativa, adelantada en el espacio ‘Los Desayunos del Parador’ de Onda Cero por José Luis Villena, delegado en Melilla del Cicode, permitirá «que tengamos aquí a Tonucci durante una semana para poder aprender y disfrutar de su magisterio», señaló Villena.
Además de este prestigioso pedagogo, en el seminario participarán Marta Román, creadora del programa ‘Camino Escolar’ del Ministerio de Educación; Juan Bautista Martínez, catedrático de la Universidad de Granada; así como Alfonso Bilbao y José Luis Cañavate, destacados urbanistas que están trabajando en los planes urbanísticos de ciudades como Málaga, Granada, Bogotá o Santiago de Chile, además del diagnóstico de la movilidad de Melilla.
El seminario trascenderá el aspecto puramente teórico y sus organizadores están trabajando en realizar visitas a centros educativos, así como en llevar a cabo una reunión de trabajo sobre las ideas de ‘La ciudad de los niños y niñas’ con representantes tanto de la Consejería como de la Dirección Provincial de Educación. Además, se pretende contar tanto con la Consejería de Fomento, Juventud y Deportes como con la de Seguridad Ciudadana para plantear acciones conjuntas de futuro. Todo lo que dé de sí el seminario será publicado en alguna editorial internacional de prestigio y de habla hispana. De momento se está trabajando con dos: Graó y Octaedro.
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Melilla conBici y el Cicode trabajan en un seminario que aborda la infancia y el urbanismo

El Centro de Iniciativas de Cooperación al Desarrollo (Cicode) y Melilla conBici están trabajando desde hace varias semanas en la realización de un Seminario sobre Urbanismo e Infancia que tendrá lugar entre los días 18 y 23 de febrero de 2013 y que contará con la presencia destacada de Francesco Tonucci, uno de los pedagogos más influyentes de las últimas décadas y creador del proyecto internacional ‘La ciudad de los niños y niñas’. La iniciativa, adelantada en el espacio ‘Los Desayunos del Parador’ de Onda Cero por José Luis Villena, delegado en Melilla del Cicode, permitirá «que tengamos aquí a Tonucci durante una semana para poder aprender y disfrutar de su magisterio», señaló Villena.
Además de este prestigioso pedagogo, en el seminario participarán Marta Román, creadora del programa ‘Camino Escolar’ del Ministerio de Educación; Juan Bautista Martínez, catedrático de la Universidad de Granada; así como Alfonso Bilbao y José Luis Cañavate, destacados urbanistas que están trabajando en los planes urbanísticos de ciudades como Málaga, Granada, Bogotá o Santiago de Chile, además del diagnóstico de la movilidad de Melilla.
El seminario trascenderá el aspecto puramente teórico y sus organizadores están trabajando en realizar visitas a centros educativos, así como en llevar a cabo una reunión de trabajo sobre las ideas de ‘La ciudad de los niños y niñas’ con representantes tanto de la Consejería como de la Dirección Provincial de Educación. Además, se pretende contar tanto con la Consejería de Fomento, Juventud y Deportes como con la de Seguridad Ciudadana para plantear acciones conjuntas de futuro. Todo lo que dé de sí el seminario será publicado en alguna editorial internacional de prestigio y de habla hispana. De momento se está trabajando con dos: Graó y Octaedro.
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El Telegrama de Melilla

Pág. 12: Las II Jornadas de Intervención en emergencias cuentan con Lola Valverde

Pág. 13: El CICODE inicia sus Proyectos Internacionales de Cooperación en su nueva edición

Descarga por URL: http://sl.ugr.es/02OR

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El Telegrama de Melilla

Pág. 12: Las II Jornadas de Intervención en emergencias cuentan con Lola Valverde

Pág. 13: El CICODE inicia sus Proyectos Internacionales de Cooperación en su nueva edición

Descarga por URL: http://sl.ugr.es/02OR

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El Faro de Melilla

Pág. 14: La participación en las V jornadas de violencia de género creció un 30%

Descarga por URL: http://sl.ugr.es/02OQ

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