Olive oil could fight cancer: study

Olive oil could fight cancer: study

Extra-virgin olive oil contains plant chemicals that combat breast cancer, a study has found.

Scientists believe the discovery may open the door to new treatments for the disease. It may also help explain why olive-rich Mediterranean diets appear to reduce the risk of breast cancer.

Extra-virgin olive oil is made from pressing olives without the use of heat or chemical treatments. Olive oil made this way contains plant chemicals that are otherwise lost in the refining process.

Researchers in Spain separated olive oil into «fractions» containing different plant chemicals, which were then tested for their effects on breast cancer cells in the laboratory.

All the fractions containing chemicals chiefly found in extra-virgin olive oil suppressed the breast cancer-promoting gene HER2 in the cells.

The compounds, known as «polyphenols», caused cells with overactive HER2 to commit suicide through a process called apoptosis.

In normal circumstances, apoptosis naturally helps to clear away defective and dangerous cells that might turn cancerous. A well known cancer drug, Herceptin, also targets the HER2 gene but is only effective in certain patients.

The scientists, led by Dr Javier Menendez, from the Catalan Institute of Oncology in Girona, and Dr Antonio Segura-Carretero, from the University of Granada, warned that the findings should be treated with caution.

They wrote in the online open access journal BMC Cancer: «The active phytochemicals… exhibited tumoricidal effects against cultured breast cancer cells at concentrations that are unlikely to be achieved in real life by consuming olive oil.»

However they added that extra-virgin olive oil polyphenols might provide «an excellent and safe platform for the design of new anti-breast cancer drugs».

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El País

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New Anti-cancer Components Of Extra-virgin Olive Oil Revealed

New Anti-cancer Components Of Extra-virgin Olive Oil Revealed

Good quality extra-virgin olive oil contains health-relevant chemicals, ‘phytochemicals’, that can trigger cancer cell death. New research sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk.

Javier Menendez from the Catalan Institute of Oncology and Antonio Segura-Carretero from the University of Granada in Spain led a team of researchers who set out to investigate which parts of olive oil were most active against cancer. Menendez said, “Our findings reveal for the first time that all the major complex phenols present in extra-virgin olive oil drastically suppress overexpression of the cancer gene HER2 in human breast cancer cells”.

Extra-virgin olive oil is the oil that results from pressing olives without the use of heat or chemical treatments. It contains phytochemicals that are otherwise lost in the refining process. Menendez and colleagues separated the oil into fractions and tested these against breast cancer cells in lab experiments. All the fractions containing the major extra-virgin phytochemical polyphenols (lignans and secoiridoids) were found to effectively inhibit HER2.

Although these findings provide new insights on the mechanisms by which good quality oil, i.e. polyphenol-rich extra-virgin olive oil, might contribute to a lowering of breast cancer risk in a HER2-dependent manner, extreme caution must be applied when applying the lab results to the human situation. As the authors point out, “The active phytochemicals (i.e. lignans and secoiridoids) exhibited tumoricidal effects against cultured breast cancer cells at concentrations that are unlikely to be achieved in real life by consuming olive oil”.

Nevertheless, and according to the authors, “These findings, together with the fact that that humans have safely been ingesting significant amounts of lignans and secoiridoids as long as they have been consuming olives and extra-virgin oil, strongly suggest that these polyphenols might provide an excellent and safe platform for the design of new anti breast-cancer drugs”.
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ABC

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El Mundo

Pág. 34: El aceite de oliva virgen extra puede frenar la expansión del cáncer de mama
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Ideal

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Innovación y Energías renovables (Especial) – Pág. 36: El papel de la universidad
Innovación y Energías renovables (Especial) – Pág. 42: Eficiencia energética y sostenibilidad
Innovación y Energías renovables (Especial) – Pág. 78: Alimentación, salud y empresa
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Desvelan nuevos componentes anticancerígenos del aceite de oliva

Desvelan nuevos componentes anticancerígenos del aceite de oliva

Un equipo de investigadores del Instituto Catalán de Oncología y la Universidad de Granada ha descubierto en estudios de laboratorio que los componentes del aceite de oliva extravirgen más activos contra el cáncer son los polifenoles denominados lignanos y secoiridoides.

Estos componentes inhiben el gen cancerígeno HER2 en células de cáncer de mama humanas en cultivo. Los resultados de su trabajo, que se publican en la revista BioMed Central, muestran que estos polifenoles podrían ser de gran utilidad en el diseño de futuras terapias.

El aceite de oliva extravirgen de buena calidad contiene componentes beneficiosos para la salud, o fitoquímicos, que pueden hacer que las células cancerígenas mueran. El estudio aporta información extra sobre la asociación entre las dietas mediterráneas ricas en aceite de oliva y la reducción en el riesgo de cáncer de mama.

Javier Menéndez, del Instituto Catalán de Oncología, y Antonio Segura-Carretero, de la Universidad de Granada, han dirigido a un equipo de investigadores españoles que ha identificado estos componentes del aceite de oliva más activos contra el cáncer.

Según explica Menéndez, «nuestros descubrimientos revelan por primera vez que los principales fenoles complejos del aceite de oliva extravirgen suprimen de forma importante la expresión excesiva del gen cancerígeno HER2 en las células del cáncer de mama humano».

El aceite de oliva extravirgen es el aceite resultante de la presión de las aceitunas sin utilizar calor o tratamientos químicos. Contiene fotoquímicos que de otra forma se perderían en el proceso de refinado del aceite. El equipo de científicos separó el aceite en mínimas partes y las evaluó frente a las células del cáncer de mama en experimentos de laboratorio. Todas las muestras de aceite que contenían los principales polifenoles del aceite extravirgen, lignanos y secoiridoides, inhibían de forma eficaz el gen HER2.

Aunque estos descubrimientos proporcionan nuevos datos sobre los mecanismos por los que la calidad del aceite de oliva, como el aceite extravirgen rico en polifenoles, podría contribuir a una reducción del riesgo del cáncer de mama que depende de HER2, los autores señalan la importancia de ser cautos al aplicar los resultados de laboratorio a una situación humana.

Los autores apuntan que «los fotoquímicos activos, como lignanos y secoiridoides, mostraron efectos tumoricidas contra las células de cáncer de mama en cultivo a concentraciones que son improbables de lograr en la vida real con el consumo de aceite de oliva».

Sin embargo, según señalan los investigadores, estos descubrimientos, junto con el hecho de la seguridad en humanos de estos componentes probada por el consumo continuado de aceitunas y de aceite extravirgen, sugieren que estos polifenoles podrían proporcionar una plataforma segura y excelente para el diseño de nuevos fármacos anticancerígenos.
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La Opinión

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El País

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Ice structures show mysteries of universe

Ice structures show mysteries of universe

Very cold ice films on interstellar dust particles are found in the universe but detailed information about the films\’ structure is not readily available, scientists say. Now state-of-the-art technology is giving researchers a heads- up to create ice films in cold conditions similar to those found in outer space, and examine the molecular organisation. This will give them the clues needed to shed light on various intriguing questions including abiogenesis.

An exploratory workshop held by the European Science Foundation (ESF) focused on the frontier research currently being undertaken on ice structures. For most people, ice is synonymous with water ice that we crave in our drinks every summer. But there is a lot more to ice than meets the eye, as was made evident in the workshop recently held in Granada, Spain, the main aim of which was to generate ideas for a future European network around this subject.

The event was co-chaired Dr Julyan Cartwright, a specialist in ice structures at the Andalusian Institute for Earth Sciences (IACT) of the Spanish Research Council (CSIC) and the University of Granada in Spain and C. Ignacio Sainz-Diaz also of the IACT.

According to Dr Cartwright, the study of these ice structures could lead to revolutionary breakthroughs in other fields as well as having many industrial applications. Some of the amazing properties of ice have long been known. For example, it is the only non-metallic substance to expand when it freezes.

The workshop however included many experimental and theoretical points of view, on not only water ice, but also other ice and solids condensed from different types of gases which exist in the extreme conditions of space. It also covered topics such as polymorphism and polyamorphism of ice, nucleation, morphology, reactivity and spectroscopy.

The main focus of the workshop was on ice in space, however. This ice exists on small grains of dust, as well as on asteroids, comets, cold moons or planets, and occasionally planets such as Earth, capable of supporting life. Perhaps the most famous of all ice in space are the rings around Saturn. These rings are made from ice particles along with other debris and dust. In the low temperatures of space, ice is formed between 3 and 90 degrees above absolute zero, where absolute zero is at minus 273.15 degrees Celsius.

At these low temperatures, ice can create different structures at the mesoscale (one size larger than the microscale) than at terrestrial conditions. In some cases these can be amorphous in form, like a glass with the molecules in effect frozen in space, rather than like a crystal.

What many researchers have seen is that under certain conditions, ice can create biomimetic forms. In other words structures that appear life-like such as palm leaves or worms, or even at a smaller scale, like bacteria. For this reason, Dr Cartwright was quick to point out that researchers should not assume that life-like forms in objects obtained from space, like Mars rock, is evidence that life actually existed there. \’If one goes to another planet and sees small wormlike or palm like structures, one should not immediately call a press conference announcing alien life has been found,\’ said Dr Cartwright.

However this ability to mimic lifelike structures suggests that nature may have copied physics. \’It is clear that biology does use physics. Indeed, how could it not do? So we shouldn\’t be surprised to see that sometimes biological structures clearly make use of simple physical principles. Then, going back in time, it seems reasonable to posit that when life first emerged, it would have been using as a container something much simpler than today\’s cell membrane, probably some sort of simple vesicle of the sort found in soap bubbles,\’ said Dr Cartwright. \’This sort of vesicle can be found in abiotic systems today, both in hot conditions, in the chemistry associated with «black smokers» on the sea floor, which is currently favoured as a possible origin of life, but also in the chemistry of sea ice.\’

This notion will be further explored in projects that have spun off from the ESF workshop.
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