Un compuesto de la aceituna puede ayudar a prevenir el cáncer

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– Un compuesto de la aceituna puede ayudar a prevenir el cáncer

El ácido maslínico, presente en la piel de la oliva, es capaz de inhibir la aparición de tumores.

Un grupo de investigadores de la Universidad de Granada (UGR) ha descubierto que el ácido maslínico, un compuesto presente en la hoja y en la cera de la piel de la aceituna, tiene la capacidad de prevenir la aparición del cáncer, así como de regular la apoptosis (muerte celular programada) en los procesos cancerígenos.

La institución universitaria explica en un comunicado que el ácido maslínico es un inhibidor de proteasas -enzimas que degradan cualquier proteína- que, entre otras propiedades, posee la capacidad de regular el crecimiento celular. Ahí es donde radica su utilidad en el tratamiento contra el cáncer, ya que permite controlar los procesos de hiperplasia e hipertrofia propios de esta enfermedad.

Los científicos de la UGR afirman que las ventajas del ácido maslínico son tres: a diferencia de otros productos anticancerígenos, se trata de un compuesto natural y, por tanto, de menor toxicidad; es selectivo, es decir, actúa sólo sobre las células cancerígenas cuyo pH es más ácido de lo normal, y posee un carácter preventivo, ya que es capaz de inhibir la aparición del cáncer en aquellas células que tienen una mayor predisposición a desarrollarlo.

La investigación se centró en el efecto del ácido maslínico en el tratamiento del cáncer de colon, aunque podría emplearse en un amplio número de tumores. Los ensayos se han realizado en ratones, pero los científicos no descartan empezar en breve las pruebas con humanos.

En la actualidad, la única planta de producción de ácido maslínico a nivel semi-industrial que hay en todo el mundo se encuentra en la Facultad de Ciencias de la UGR.
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Un compuesto de la aceituna evita el crecimiento de células cancerígenas y previene su aparición

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– Un compuesto de la aceituna evita el crecimiento de células cancerígenas y previene su aparición – Industria
Universidad de Granada

Científicos de la Universidad de Granada han descubierto que el ácido maslínico, presente en la hoja y cera de la piel de la aceituna, actúa sobre las células tumorales controlando sus alteraciones en los procesos de crecimiento. En la actualidad, la única planta de producción semi-industrial de esta sustancia a nivel semi-industrial que hay en todo el mundo se encuentra en la Facultad de Ciencias de la UGR.

15 Febrero ´08- Un grupo de investigadores de la Universidad de Granada ha descubierto que el ácido maslínico, un compuesto presente en la hoja y en la cera de la piel de la aceituna que se extrae del alpeorujo, tiene la capacidad de prevenir la aparición de cáncer, así como de regular la apoptosis en los procesos cancerígenos.

El ácido maslínico es un inhibidor de proteasas que, entre otras propiedades, posee la capacidad de regular el crecimiento celular. Es ahí donde radica su utilidad en el tratamiento contra el cáncer, ya que permite controlar los procesos de hiperplasia e hipertrofia propios de esta enfermedad. Los científicos de la UGR han caracterizado por primera vez la acción del ácido maslínico desde el punto de vista molecular cuando es aplicado al desarrollo de células tumorales.

Este trabajo ha sido realizado por el doctorando Fernando Jesús Reyes Zurita, y dirigido por el profesor José Antonio Lupiáñez Cara , del departamento de Bioquímica y Biología Molecular I. A juicio de ambos científicos, las ventajas del ácido maslínico son tres: a diferencia de otros productos anticancerígenos, altamente citotóxicos, se trata de un compuesto natural y por tanto de menor toxicidad. Además, es selectivo, es decir, actúa sólo sobre las células cancerígenas, cuyo pH es más ácido de lo normal. Y en último lugar, posee un carácter preventivo, ya que es capaz de inhibir la aparición del cáncer, en aquellas células que tienen una mayor predisposición de desarrollarlo.

Para todo tipo de cáncer

Aunque el grupo de investigación del profesor Lupiáñez Cara ha analizado el efecto del ácido maslínico en el tratamiento del cáncer de colon, si bien podría emplearse en un amplio número de tumores. De momento, sus investigaciones se han realizado en líneas de carcinomas de colon y en ratones transgénicos, pero no descartan poder aplicarlas a humanos en un futuro.

El ácido maslínico es un terpeno pentacíclico que además de ser anticancerígeno posee efectos antiinflamatorios y antioxidantes, y que se encuentra en elevadas concentraciones en la cera de la piel de la aceituna. En la actualidad, la única planta de producción de esta sustancia a nivel semi-industrial que hay en todo el mundo se encuentra en la Facultad de Ciencias de la Universidad de Granada.
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Farmacéuticos analizan los «retos» de los medicamentos

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– Farmacéuticos analizan los retos de los medicamentos
El Colegio Oficial de Cádiz conmemora sus 150 años de existencia

Analizar los retos y desafíos de los medicamentos en la sociedad es el principal tema de debate del simposio farmacéutico que se celebrará en Cádiz hasta mañana con motivo de la celebración de los 150 años del Colegio de Farmacéuticos.

Importantes especialistas en Historia, Farmacia y Medicina y los máximos representantes de la organización farmacéutica colegial en Andalucíay España se darán cita en la ciudad para estudiar el presente, el pasado y el porvenir de la profesión farmacéutica.

Este acto tiene intención de trascender la conmemoración del aniversario del Colegio de Farmacéuticos de Cádiz, el más antiguo del país, para convertirse en una reflexión sobre la historia de la Farmacia. El catedrático de la Facultad de Farmacia de la Universidad de Granada, José Luis Valverde, explicó ayer en el acto de presentación de este evento que la esperanza de vida en el año 58, cuando se fundó el Colegio de Farmacéuticos de Cádiz, era de 35 años y hoy es de 87 en las mujeres y de 83 en los hombres. Valverde añadió que “este avance es gracias a la valía de los medicamentos que aumentan la longevidad y calidad de vida”.

Asimismo, el catedrático lamentó que España “no in vierta lo suficiente en medicamentos, menos del 1% del Producto Interior Bruto, cuando lo mínimo tendría que ser el 3%. Es uno de los países que invierte menos en este sector”. La dimensión económica de los medicamentos es otro de los puntos a debatir en las mesas redondas celebran en el Consistorio gaditano.

Por otro lado, el presidente del Colegio de Farmacéuticos de Cádiz Felipe Trigo, concretó que con estas conferencias harán ver cómo el farmacéutico “ha sido siempre el agente sanitario más cercano al ciudadano”, a la vez que defendió que el profesional farmacéutico es un “rol que consideremos crucial que se mantenga en el futuro”.

Hoy se celebrarán tres mesas redondas que abordarán los más diversos enfoques de la evolución de la historia de la Farmacia.
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Olive Compound Inhibits Cancer Cells Growth and Prevents Their Appearance

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– Olive Compound Inhibits Cancer Cells Growth and Prevents Their Appearance

Maslinic acid is a protease inhibitor that, among other features, has the capacity of regulating cell growth. It is useful for cancer treatment, as it allows to control the hyperplasia and hypertrophy processes, typical of this disease.

A research group of the University of Granada has found out that maslinic acid, a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp), has the capacity of preventing cancer as well as regulating apoptosis in carcinogenic processes.

Maslinic acid is a protease inhibitor that, among other features, has the capacity of regulating cell growth. It is useful for cancer treatment, as it allows to control the hyperplasia and hypertrophy processes, typical of this disease. The scientists of the UGR have characterized for the first time maslinic acid action from the molecular point of view when it is applied to the development of tumour cells.

This work has been carried out by Ph D student Fernando Jesús Reyes Zurita, and directed by Professor José Antonio Lupiáñez Cara, of the department of Biochemistry and Molecular Biology I. According to them, the advantages of maslinic acid are three: Unlike other anti-carcinogenic products, highly cytotoxic, it is a natural compound and, therefore, less toxic. In addition, it is selective, this is, it only acts on carcinogenic cells, whose pH is more acid than usual. And lastly, it has a preventive nature, as it can inhibit cancer appearance in those cells with a higher predisposition to develop it.

Although the research group of Professor Lupiáñez Cara has analysed the effect of maslinic acid in the treatment of colon cancer, it can be used in different types of tumours. For the moment, their research works have been developed in colon carcinoma lines and transgenic mice, but they have not dismissed the possibility of applying them to humans in future.

Maslinic acid is a pentacyclic terpene which, besides being anti-carcinogenic, it has anti-inflammatory and antioxidant effects and can be found in high concentrations in olive skin wax. At present, the only production plant of this substance at a semi-industrial level in the whole world is at the Faculty of Sciences of the University of Granada.

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A natural compound extracted from olive inhibits cancer cells growth and prevents their appearance

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– A natural compound extracted from olive inhibits cancer cells growth and prevents their appearance

A research group of the University of Granada has found out that maslinic acid, a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp), has the capacity of preventing cancer as well as regulating apoptosis in carcinogenic processes.

Maslinic acid is a protease inhibitor that, among other features, has the capacity of regulating cell growth. It is useful for cancer treatment, as it allows to control the hyperplasia and hypertrophy processes, typical of this disease. The scientists of the UGR have characterized for the first time maslinic acid action from the molecular point of view when it is applied to the development of tumour cells.

This work has been carried out by Ph D student Fernando Jesús Reyes Zurita, and directed by Professor José Antonio Lupiáñez Cara, of the department of Biochemistry and Molecular Biology I. According to them, the advantages of maslinic acid are three: Unlike other anti-carcinogenic products, highly cytotoxic, it is a natural compound and, therefore, less toxic. In addition, it is selective, this is, it only acts on carcinogenic cells, whose pH is more acid than usual. And lastly, it has a preventive nature, as it can inhibit cancer appearance in those cells with a higher predisposition to develop it.

For all types of cancer

Although the research group of Professor Lupiáñez Cara has analysed the effect of maslinic acid in the treatment of colon cancer, it can be used in different types of tumours. For the moment, their research works have been developed in colon carcinoma lines and transgenic mice, but they have not dismissed the possibility of applying them to humans in future.

Maslinic acid is a pentacyclic terpene which, besides being anti-carcinogenic, it has anti-inflammatory and antioxidant effects and can be found in high concentrations in olive skin wax. At present, the only production plant of this substance at a semi-industrial level in the whole world is at the Faculty of Sciences of the University of Granada.
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ALIMENTAZIONE: SPERANZE PER CANCRO DA UN ESTRATTO DALLE OLIVE

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– ALIMENTAZIONE: SPERANZE PER CANCRO DA UN ESTRATTO DALLE OLIVE

Un composto estratto dalle olive e capace di inibire la crescita delle cellule tumorali e di impedire la loro comparsa. A sostenerlo e stato un gruppo di ricercatori dellUniversita di Granada in uno studio pubblicato sulla rivista Febs Letters. I ricercatori hanno scoperto che lacido maslinico, un composto presente nelle foglie e nella cera che riveste la buccia delle olive, e in grado di prevenire il cancro, nonche di regolare lapoptosi, la morte cellulare, nei processi cancerogeni. Lacido maslinico e un inibitore della proteasi, un enzima che, tra le altre caratteristiche, ha la capacita di regolare la crescita cellulare. Quindi questo composto e efficace nel trattamento del cancro perche consente di controllare i processi di iperplasia e ipertrofia, tipici della patologia tumorale. I ricercatori hanno analizzato per la prima volta lazione dellacido maslinico, dal punto di vista molecolare, quando agisce sullo sviluppo delle cellule tumorali. Dai risultati dello studio e emerso che sono tre i vantaggi dellacido maslinico: a differenza di altri farmaci contro il cancro e un composto naturale e, di conseguenza, e meno tossico. Poi lacido agisce in maniera selettiva, ovvero solo sulle cellule cancerogene, il cui pH e particolarmente acido. E, infine, ha un potere preventivo, in quanto esso puo inibire la comparsa del cancro.
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Researchers at the University of Granada have discovered a compound in olives that can help in preventing cancer.

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– Researchers at the University of Granada have discovered a compound in olives that can help in preventing cancer.

Researchers at the University of Granada have discovered a compound in olives that can help in preventing cancer.

Maslinic acid is a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp) that can regulate cancer cell growth and prevents their appearance.

The acid controls the hyperplasia, proliferation of cells within an organ or tissue and hypertrophy, the increase of the size of an organ or in a select area of the tissue, typical of this disease.

According to lead researchers Professor Jose Antonio Lupianez Cara, of the department of Biochemistry and Molecular Biology I and Ph D student Fernando Jesus Reyes Zurita, unlike other anti-carcinogenic products, maslinic acid is a natural compound, thus is less toxic. In addition it only acts on carcinogenic cells, whose pH is more acid than usual and can inhibit cancer appearance in those cells with a higher predisposition to develop it.

Though the researchers only analysed the effect of maslinic acid in the treatment of colon cancer but they have said that it can be used in different types of tumours. (ANI)
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Olive compound may prevent cancer

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– Olive compound may prevent cancer

Researchers at the University of Granada have discovered a compound in olives that can help in preventing cancer.

Maslinic acid is a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp) that can regulate cancer cell growth and prevents their appearance.

The acid controls the hyperplasia, proliferation of cells within an organ or tissue and hypertrophy, the increase of the size of an organ or in a select area of the tissue, typical of this disease.

According to lead researchers Professor Jose Antonio Lupianez Cara, of the department of Biochemistry and Molecular Biology I and Ph D student Fernando Jesus Reyes Zurita, unlike other anti-carcinogenic products, maslinic acid is a natural compound, thus is less toxic. In addition it only acts on carcinogenic cells, whose pH is more acid than usual and can inhibit cancer appearance in those cells with a higher predisposition to develop it.

Though the researchers only analysed the effect of maslinic acid in the treatment of colon cancer but they have said that it can be used in different types of tumours.

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Alimentazione infantile: bambini sani, adulti più in salute

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– Alimentazione infantile: bambini sani, adulti più in salute.

Allinizio dellanno, scienziati di 16 paesi hanno unito le forze per iniziare a studiare il legame che intercorre tra lalimentazione nellinfanzia e linsorgenza di malattie in età adulta, quali il diabete o le allergie.

I primi anni di sviluppo di un bambino esercitano un impatto profondo sullo stesso, che si protrae fino alletà adulta, gli scienziati hanno appena iniziato a scoprire quanto può essere significativo nel tempo limpatto dei primi anni di sviluppo per il benessere in età adulta, un progetto europeo sta raccogliendo dati che saranno utili per linquadramento della politica negli anni a venire.

Allinizio dellanno, scienziati di 16 paesi hanno unito le forze per iniziare a studiare il legame che intercorre tra lalimentazione nellinfanzia e linsorgenza di malattie in età adulta, quali il diabete o le allergie. Liniziativa ambiziosa è la prima del genere di così ampio respiro in Europa.

Guida liniziativa la professoressa Cristina Campoy Folgoso, la quale ci tiene a sottolineare che la programmazione dellalimentazione nei primi anni di vita è un tema recente nel campo della salute e della scienza. «Studi diversi dimostrano che gli alimenti possono avere conseguenze a lungo termine per la crescita dei bambini, la salute durante la gravidanza, il periodo di allattamento e linfanzia. Inoltre, lalimentazione può influire sullinsorgenza delle malattie in età adulta», ha dichiarato.

Finanziato dalla Commissione europea, il progetto EARNEST, ossia Early Nutrition Programming Project (Progetto per la programmazione dellalimentazione nellinfanzia), si propone di contribuire alla formulazione di politiche, campagne di informazione, documenti, guide e raccomandazioni sugli elementi nutrizionali degli alimenti per bambini e per il miglioramento degli alimenti in polvere per neonati. Collabora inoltre nellelaborazione di piani volti a prevenire ed evitare gli effetti dellalimentazione sul metabolismo.

A tal fine, i ricercatori del reparto di pediatria dellUniversità di Granada hanno avviato una collaborazione con altre 38 università e imprese di 16 paesi europei. I loro sforzi congiunti aiuteranno i ricercatori ad avere una comprensione maggiore degli effetti dellalimentazione nellinfanzia sullinsorgenza di problemi cardiovascolari, diabete, obesità, allergie, debolezza delle ossa, funzionalità del motoneurone e aspetti comportamentali dei bambini.

Il progetto effettuerà sperimentazioni cliniche assegnate casualmente e interventi di tipo alimentare durante la gravidanza e linfanzia, condurrà inoltre studi pilota, test sugli animali, sulle cellule e sul genomita. Léquipe esaminerà inoltre studi sociali ed economici correlati alla nutrizione nelle prime fasi della vita e alla sua rilevanza nellinsorgenza successiva di malattie.

I ricercatori sperano di trovare il meccanismo genetico di patologie quali il diabete e lobesità. è comunemente noto che la cinetica della crescita nei bambini allattati al seno differisce da quella dei piccoli alimentati con latte artificiale, che tendono ad aumentare più facilmente di peso e di altezza. «Lobesità sta diventando unepidemia globale e inizia in parte durante lo sviluppo infantile», ha spiegato la professoressa Campoy Folgoso. Considerando le conseguenze, uno degli scopi del progetto è studiare se lallattamento al seno possa prevenire il rischio di obesità negli anni successivi.

I paesi che partecipano al progetto sono Bielorussia, Belgio, Repubblica ceca, Danimarca, Finlandia, Francia, Germania, Ungheria, Italia, Paesi Bassi, Norvegia, Polonia, Spagna, Svezia, Svizzera e Regno Unito.
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Olive pulp compound inhibits cancer

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– Olive pulp compound inhibits cancer

A research group of the University of Granada has found out that maslinic acid, a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp), has the capacity of preventing cancer as well as regulating apoptosis in carcinogenic processes.

Maslinic acid is a protease inhibitor that, among other features, has the capacity of regulating cell growth. It is useful for cancer treatment, as it allows to control the hyperplasia and hypertrophy processes, typical of this disease. The scientists of the UGR have characterised for the first time maslinic acid action from the molecular point of view when it is applied to the development of tumour cells.

This work has been carried out by Ph D student Fernando Jesús Reyes Zurita, and directed by Professor José Antonio Lupiáñez Cara, of the department of Biochemistry and Molecular Biology I. According to them, the advantages of maslinic acid are three: Unlike other anti-carcinogenic products, highly cytotoxic, it is a natural compound and, therefore, less toxic. In addition, it is selective, this is, it only acts on carcinogenic cells, whose pH is more acid than usual. And lastly, it has a preventive nature, as it can inhibit cancer appearance in those cells with a higher predisposition to develop it.

For all types of cancer

Although the research group of Professor Lupiáñez Cara has analysed the effect of maslinic acid in the treatment of colon cancer, it can be used in different types of tumours. For the moment, their research works have been developed in colon carcinoma lines and transgenic mice, but they have not dismissed the possibility of applying them to humans in future.

Maslinic acid is a pentacyclic terpene which, besides being anti-carcinogenic, it has anti-inflammatory and antioxidant effects and can be found in high concentrations in olive skin wax. At present, the only production plant of this substance at a semi-industrial level in the whole world is at the Faculty of Sciences of the University of Granada.
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Olives inhibit cancer cells growth and prevents their appearance

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– Olives inhibit cancer cells growth and prevents their appearance.

A research group of the University of Granada has found out that maslinic acid, a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp), has the capacity of preventing cancer as well as regulating apoptosis in carcinogenic processes.

Maslinic acid is a protease inhibitor that, among other features, has the capacity of regulating cell growth. It is useful for cancer treatment, as it allows to control the hyperplasia and hypertrophy processes, typical of this disease. The scientists of the UGR have characterized for the first time maslinic acid action from the molecular point of view when it is applied to the development of tumour cells.

This work has been carried out by Ph D student Fernando Jes?s Reyes Zurita, and directed by Professor Jos? Antonio Lupi??ez Cara, of the department of Biochemistry and Molecular Biology I. According to them, the advantages of maslinic acid are three: Unlike other anti-carcinogenic products, highly cytotoxic, it is a natural compound and, therefore, less toxic. In addition, it is selective, this is, it only acts on carcinogenic cells, whose pH is more acid than usual. And lastly, it has a preventive nature, as it can inhibit cancer appearance in those cells with a higher predisposition to develop it.

For all types of cancer

Although the research group of Professor Lupi??ez Cara has analysed the effect of maslinic acid in the treatment of colon cancer, it can be used in different types of tumours. For the moment, their research works have been developed in colon carcinoma lines and transgenic mice, but they have not dismissed the possibility of applying them to humans in future.

Maslinic acid is a pentacyclic terpene which, besides being anti-carcinogenic, it has anti-inflammatory and antioxidant effects and can be found in high concentrations in olive skin wax. At present, the only production plant of this substance at a semi-industrial level in the whole world is at the Faculty of Sciences of the University of Granada.-Universidad de Granada

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Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer

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– Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer

In the 1960s, Ancer Keys, a US expert on nutrition, studied the health benefits of the Mediterranean diet for the first time. Since then many studies on the benefits of olive oil have been conducted. According to several studies performed in Italy, Spain and Greece (the main olive-oil-producing countries), the incidence of diseases is lower in these countries than in Northern Europe.

The Environmental, Biochemical and Nutritional Analytical-Control Research Group, directed by Professors Alberto Fernndez Gutirrez and Antonio Segura Carretero, used the most advanced analytical techniques for a precise study on the antioxidant properties of olive oil, characterized by its polyphenolic composition and its potential to combat degenerative diseases.

The study was completed with the collaboration of the Institut of Nutrition and Food Technology of the University of Granada and the Nutrition Team of the Hospital Virgen de las Nieves (Granada). Together with the Research Group, they have determined that consumption of olive oil rich in polyphenols (natural antioxidants) improves the lives of people suffering from oxidative stress, and is also highly beneficial for the prevention of cell aging and osteoporosis.

This research has stirred the interest of the Control Board of the Designation of Origin Sierra Segura. After analysing samples from 15 olive oil mills, researchers have demonstrated that olive oil is very rich in polyphenols. According to Professors Alberto Fernndez and Antonio Segura, as preventive substances, polyphenols help to combat any oxidative disease associated with the degenerative process.

The Environmental, Biochemical and Nutritional Analytical-Control Research Group of the University of Granada has carried out several related studies, such as the creation of a system aimed at guaranteeing the quality of bee honey and determining its geographical origin, or the polyphenolic characterization of food products such as honey, beer and propolis.

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