High cholesterol diet changes cells

– High cholesterol diet changes cells

A high cholesterol diet causes changes in the genes of aortic smooth muscle cells in chickens at the early stages of arteriosclerosis, found a Spanish study.
The study associates cholesterol intake with the expression of genes codifying certain proteins, even before the disease is detected on blood vessel walls, according to researchers at the University of Granada.

A 20-day high cholesterol diet is enough to detect atheromatous plaques in the arteries of chickens. Ten days after the start of the high cholesterol diet — when atheromatous plaques are not still visible using an electron microscope — aortic smooth muscle cells were extracted and in-vitro cultured.

After genetic analysis, scientists found cholesterol causes changes in messenger RNA synthesis in proteins related to lipid metabolism control.

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