Seminario «Exploring the Impact of Nanoparticle Stealth Coatings in Cancer Models»

Pablo Graván Jiménez (Departamento Física Aplicada / BioFab i3D-Biofabrication and 3D (bio)printing laboratory, Universidad de Granada) expondrá el seminario titulado «Exploring the Impact of Nanoparticle Stealth Coatings in Cancer Models: From PEGylation to Cell Membrane Coating Nanotechnology».

Resumen:

Nanotechnological platforms offer advantages over conventional therapeutic and diagnostic modalities. However, efficient biointerfacing of nanomaterials for biomedical applications remains challenging. In recent years, nanoparticles with different coatings have been developed to reduce non-specific interactions, prolong circulation time, and improve therapeutic outcomes. This study aims to compare various nanoparticle coatings to enhance surface engineering for more effective nanomedicines. We prepared and characterized polystyrene nanoparticles with different coatings of polyethylene glycol, bovine serum albumin, chitosan, and cell membranes from a human breast cancer cell line. The coating was found to affect colloidal stability, adhesion, and the elastic modulus of NPs. Protein corona formation and cellular uptake of NPs were also investigated, and a 3D tumor model was employed to provide a more realistic representation of the tumor microenvironment. The prepared NPs were found to reduce protein adsorption, and cell membrane-coated nanoparticles showed significantly higher cellular uptake. The secretion of proinflammatory cytokines of human monocytes after incubation with the prepared NPs was evaluated. Overall, the study demonstrates the importance of coatings in affecting the behavior and interaction of nanosystems with biological entities. The findings provide insight into bio-nano interactions and are important for the effective implementation of stealth surface engineering designs.

• Fecha: Jueves, 4 de julio de 2024
• Lugar: Facultad de Ciencias – Aula A24.
• Horario: de 12:30 a 13:30 h
• Organiza: Departamento de Física Aplicada – Grupo de Física de Fluidos y Biocoloides
• Más información: http://biocol.ugr.es