Bioinfo Club: «Insights from quantitative modelling of alternative splicing evolution»

BioInformaticsGRX, comunidad granadina para el estudio y el desarrollo de la bioinformática, presenta BioInfo Club, un ciclo de conferencias mensuales centradas en la BioInformática con invitados de toda españa.

El próximo evento es la charla “Insights from quantitative modelling of alternative splicing evolution”, que será impartida en inglés por Carlos Martí-Gomez (Centro Nacional Investigacion Cardiovascular).

Descripción:
Alternative splicing (AS) enables the generation of different transcript isoforms from a single gene. 95% of human multiexonic genes produce more than a single mRNA through AS and there are many well established examples of how AS can produce mRNAs encoding proteins with different functionality. However, as in any biological process, errors occur during the processing of the pre-mRNA. To what extent the observed transcriptomics diversity derives from splicing errors or functional AS remains controversial. In this work we will study how AS patterns have evolved during mammalian diversification and try to dissect the role played by natural selection. We will show how models of evolution of quantitative traits can help us better understand the contribution of AS to transcriptome diversity and their evolutionary implications at a genome-wide level.

• Fecha: Martes 16 de febrero de 2021
• Hora: 19:00-20:00h
• Registro: https://bioinformaticsgrx.es/online 
• Más información: https://bioinformaticsgrx.es/evento/bioinfo-club-feb-insights-from-quantitative-modelling-of-alternative-splicing-evolution/