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Natural extracts show obesity fighting potential: Rat study Natural extracts show obesity fighting potential: Rat study

suggest researchers.

 

Scientists from the University of Granada, Spain, identified the four plant extracts that could help in preventing and fighting obesity

through a series of in vitro tests on potential fat fighting compounds.

The most effective extracts in the test­tube w ere subsequently tested for their anti­obesity potential in rats.

The authors, led by Belén San Román Arenas, from the Biosearch Life Department of Research at Granada, said that w hilst the results

from their investigation are promising, further studies on animals are required to evaluate and confirm the anti­obesity effects of the

extracts. They explained that once the effects are confirmed in animals, the extracts w ill then be tested on humans.

Román Arenas said the extracts selected in the study come from vegetables commonly consumed by humans, and can be used as

nutritional supplements or added to food w ithout problems, “once their effectiveness is tested and verified on humans.”

Study details

The researchers said that their research revealed that tw o of the extracts ­ w hich name cannot be disclosed for confidentiality

reasons ­ inhibited the activity of an enzyme that is important in the breakdow n of dietary lipids. As such the extracts w ere show n to

reduce lipid absorption.

In addition, the assays uncovered tw o further extracts, w hich w ere found to induce the breakdow n ​ of triglycerides accumulated

w ithin fat cells – thus reducing their fat content.

The researchers reported that rats fed w ith a fat­rich diet supplemented w ith the extracts that demonstrated potential in blocking fat

absorption show ed a 6­8% increase in the fat excreted in feces – compared to rats fed w ith a fat­rich diet w ithout any supplementary

extract.

They added that obese rats administered the tw o potentially fat reducing extracts w ere found to have low er fat cell contents after ten

w eeks.

“Lipid concentrations in plasma improved as did the parameters associated w ith the metabolism of glucose ­w hich is related w ith

diabetes and obesity,” said the researchers.

Román Arenas revealed that dietary administration of one of the extracts to obese rats “significantly reduced triglyceride and

cholesterol levels in plasma by 67 and 49% respectively” – compared to a control group of obese rats that received no extracts.

Glucose and insulin levels in plasma w ere also significantly improved, they reported.

suggest researchers.Scientists from the University of Granada, Spain, identified the four plant extracts that could help in preventing and fighting obesitythrough a series of in vitro tests on potential fat fighting compounds.The most effective extracts in the test­tube w ere subsequently tested for their anti­obesity potential in rats.The authors, led by Belén San Román Arenas, from the Biosearch Life Department of Research at Granada, said that w hilst the resultsfrom their investigation are promising, further studies on animals are required to evaluate and confirm the anti­obesity effects of theextracts. They explained that once the effects are confirmed in animals, the extracts w ill then be tested on humans.Román Arenas said the extracts selected in the study come from vegetables commonly consumed by humans, and can be used asnutritional supplements or added to food w ithout problems, “once their effectiveness is tested and verified on humans.”Study detailsThe researchers said that their research revealed that tw o of the extracts ­ w hich name cannot be disclosed for confidentialityreasons ­ inhibited the activity of an enzyme that is important in the breakdow n of dietary lipids. As such the extracts w ere show n toreduce lipid absorption. ​In addition, the assays uncovered tw o further extracts, w hich w ere found to induce the breakdow n ​ of triglycerides accumulatedw ithin fat cells – thus reducing their fat content.The researchers reported that rats fed w ith a fat­rich diet supplemented w ith the extracts that demonstrated potential in blocking fatabsorption show ed a 6­8% increase in the fat excreted in feces – compared to rats fed w ith a fat­rich diet w ithout any supplementaryextract.They added that obese rats administered the tw o potentially fat reducing extracts w ere found to have low er fat cell contents after tenw eeks.”Lipid concentrations in plasma improved as did the parameters associated w ith the metabolism of glucose ­w hich is related w ithdiabetes and obesity,” said the researchers.Román Arenas revealed that dietary administration of one of the extracts to obese rats “significantly reduced triglyceride andcholesterol levels in plasma by 67 and 49% respectively” – compared to a control group of obese rats that received no extracts.Glucose and insulin levels in plasma w ere also significantly improved, they reported.

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